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Hnrnpc heterogeneous nuclear ribonucleoprotein C [ Mus musculus (house mouse) ]

Gene ID: 15381, updated on 1-Mar-2024

Summary

Official Symbol
Hnrnpcprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein Cprovided by MGI
Primary source
MGI:MGI:107795
See related
Ensembl:ENSMUSG00000060373 AllianceGenome:MGI:107795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpc; Hnrpc1; Hnrpc2; hnRNPC1; hnRNPC2; hnrnp-C; D14Wsu171e
Summary
Enables mRNA binding activity. Predicted to be involved in negative regulation of mRNA modification. Predicted to act upstream of or within RNA splicing and mRNA processing. Located in pronucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to several human genes including HNRNPC (heterogeneous nuclear ribonucleoprotein C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 123.0), CNS E14 (RPKM 61.1) and 23 other tissues See more
Orthologs
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Genomic context

See Hnrnpc in Genome Data Viewer
Location:
14 C2; 14 26.79 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52310834..52341462, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52073377..52104039, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22354 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene retinitis pigmentosa GTPase regulator interacting protein 1 Neighboring gene MRT4, mRNA turnover 4, homolog pseudogene Neighboring gene SPT16, facilitates chromatin remodeling subunit Neighboring gene STARR-positive B cell enhancer ABC_E7310 Neighboring gene STARR-seq mESC enhancer starr_36700

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N6-methyladenosine-containing RNA reader activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables deaminase binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mRNA modification ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasmic periphery of the nuclear pore complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoproteins C1/C2
Names
heterogeneous nuclear ribonucleoprotein C1
heterogeneous nuclear ribonucleoprotein C2
heterogeneous ribonucleoprotein C1/C2
hnRNP C1 / hnRNP C2
hnRNP C1/C2
hnRNP C2
snoRNA MBI-122

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170981.3NP_001164452.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

    See identical proteins and their annotated locations for NP_001164452.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2, 3 and 13 encode the same isoform (2).
    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88662.1
    UniProtKB/TrEMBL
    Q3U6P5
    Related
    ENSMUSP00000154757.2, ENSMUST00000227242.2
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  2. NM_001170982.3NP_001164453.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

    See identical proteins and their annotated locations for NP_001164453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2, 3 and 13 encode the same isoform (2).
    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88662.1
    UniProtKB/TrEMBL
    Q3U6P5
    Related
    ENSMUSP00000154737.2, ENSMUST00000227536.2
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  3. NM_001170983.3NP_001164454.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

    See identical proteins and their annotated locations for NP_001164454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. Variants 4, 14, 15 and 16 encode the same isoform (3).
    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88661.1
    UniProtKB/Swiss-Prot
    Q9Z204
    Related
    ENSMUSP00000154166.2, ENSMUST00000228748.2
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  4. NM_001170984.3NP_001164455.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

    See identical proteins and their annotated locations for NP_001164455.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. Variants 5, 17 and 18 encode the same isoform (4).
    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88660.1
    UniProtKB/TrEMBL
    Q3U6P5
    Related
    ENSMUSP00000154238.2, ENSMUST00000227458.2
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  5. NM_001360172.2NP_001347101.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS36917.1
    UniProtKB/Swiss-Prot
    Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
    UniProtKB/TrEMBL
    Q3U6P5
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  6. NM_001360173.2NP_001347102.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS36917.1
    UniProtKB/Swiss-Prot
    Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
    UniProtKB/TrEMBL
    Q3U6P5
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  7. NM_001360174.2NP_001347103.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88659.1
    Related
    ENSMUSP00000154212.2, ENSMUST00000228198.2
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  8. NM_001360175.2NP_001347104.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88659.1
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  9. NM_001360176.2NP_001347105.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC157572
    UniProtKB/TrEMBL
    Q3U6P5
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  10. NM_001360177.2NP_001347106.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC157572
    UniProtKB/TrEMBL
    Q3U6P5
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  11. NM_001360178.2NP_001347107.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC157572
    UniProtKB/TrEMBL
    Q3U6P5
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  12. NM_001360179.2NP_001347108.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88662.1
    UniProtKB/TrEMBL
    Q3U6P5
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  13. NM_001360180.2NP_001347109.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88661.1
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  14. NM_001360181.2NP_001347110.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88661.1
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  15. NM_001360182.2NP_001347111.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88661.1
    Related
    ENSMUSP00000154619.2, ENSMUST00000228232.2
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  16. NM_001360183.2NP_001347112.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88660.1
    UniProtKB/TrEMBL
    Q3U6P5
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  17. NM_001360184.2NP_001347113.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS88660.1
    UniProtKB/TrEMBL
    Q3U6P5
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
  18. NM_001424475.1NP_001411404.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157572
    UniProtKB/TrEMBL
    Q3U6P5
  19. NM_001424476.1NP_001411405.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157572
    UniProtKB/TrEMBL
    Q3U6P5
  20. NM_001424477.1NP_001411406.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157572
  21. NM_001424478.1NP_001411407.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157572
    UniProtKB/Swiss-Prot
    Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
    UniProtKB/TrEMBL
    Q3U6P5
  22. NM_001424479.1NP_001411408.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157572
    UniProtKB/TrEMBL
    Q3U6P5
  23. NM_001424480.1NP_001411409.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157572
    UniProtKB/TrEMBL
    Q3U6P5
  24. NM_001424481.1NP_001411410.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC157572
    UniProtKB/TrEMBL
    Q3U6P5
  25. NM_001424482.1NP_001411411.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157572
  26. NM_016884.5NP_058580.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

    See identical proteins and their annotated locations for NP_058580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1, 6 and 7 encode the same isoform (1).
    Source sequence(s)
    AC157572
    Consensus CDS
    CCDS36917.1
    UniProtKB/Swiss-Prot
    Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
    UniProtKB/TrEMBL
    Q3U6P5
    Related
    ENSMUSP00000107237.5, ENSMUST00000111610.12
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52310834..52341462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158467.1XP_036014360.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
    UniProtKB/TrEMBL
    Q3U6P5
    Conserved Domains (1) summary
    cd12603
    Location:1093
    RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)