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SH3RF2 SH3 domain containing ring finger 2 [ Homo sapiens (human) ]

Gene ID: 153769, updated on 5-Aug-2022

Summary

Official Symbol
SH3RF2provided by HGNC
Official Full Name
SH3 domain containing ring finger 2provided by HGNC
Primary source
HGNC:HGNC:26299
See related
Ensembl:ENSG00000156463 MIM:613377; AllianceGenome:HGNC:26299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEPP1; POSHER; RNF158; PPP1R39
Summary
Enables protein phosphatase 1 binding activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of cellular protein metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 22.7), testis (RPKM 19.4) and 12 other tissues See more
Orthologs
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Genomic context

See SH3RF2 in Genome Data Viewer
Location:
5q32
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (145936578..146081773)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (146470962..146597631)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145316141..145442855)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr5.3602 Neighboring gene glutaredoxin and cysteine rich domain containing 2 Neighboring gene uncharacterized LOC107986458 Neighboring gene Sharpr-MPRA regulatory region 2549 Neighboring gene apolipoprotein O like pseudogene Neighboring gene uncharacterized LOC107986459 Neighboring gene PLAC8 like 1 Neighboring gene leucyl-tRNA synthetase 1 Neighboring gene ribosomal protein L35a pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23654, MGC90410, MGC149788, MGC149789

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SH3RF2
Names
POSH-eliminating RING protein
RING finger protein 158
RING-type E3 ubiquitin transferase SH3RF2
SH3 domain-containing RING finger protein 2
heart protein phosphatase 1-binding protein
phosphatase 1 binding protein
protein phosphatase 1 regulatory subunit 39
putative E3 ubiquitin-protein ligase SH3RF2
NP_689763.4
XP_006714820.1
XP_011535869.1
XP_011535870.1
XP_016864625.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152550.4NP_689763.4  E3 ubiquitin-protein ligase SH3RF2

    Status: VALIDATED

    Source sequence(s)
    AC005216, AC005351, AC011359, AC091887
    Consensus CDS
    CCDS4280.1
    UniProtKB/Swiss-Prot
    Q96LP8
    Related
    ENSP00000352028.4, ENST00000359120.9
    Conserved Domains (4) summary
    cd11784
    Location:384438
    SH3_SH3RF2_3; Third Src Homology 3 domain of SH3 domain containing ring finger 2
    cd11929
    Location:128181
    SH3_SH3RF2_1; First Src Homology 3 domain of SH3 domain containing ring finger 2
    cd11932
    Location:191247
    SH3_SH3RF2_2; Second Src Homology 3 domain of SH3 domain containing ring finger 2
    cd16749
    Location:1155
    RING-HC_SH3RF2; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 2 (SH3RF2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    145936578..146081773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714757.2XP_006714820.1  E3 ubiquitin-protein ligase SH3RF2 isoform X2

    See identical proteins and their annotated locations for XP_006714820.1

    UniProtKB/Swiss-Prot
    Q8TEC5, Q96LP8
    Conserved Domains (4) summary
    cd11784
    Location:384438
    SH3_SH3RF2_3; Third Src Homology 3 domain of SH3 domain containing ring finger 2
    cd11929
    Location:128181
    SH3_SH3RF2_1; First Src Homology 3 domain of SH3 domain containing ring finger 2
    cd11932
    Location:191247
    SH3_SH3RF2_2; Second Src Homology 3 domain of SH3 domain containing ring finger 2
    cd16749
    Location:1155
    RING-HC_SH3RF2; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 2 (SH3RF2) and similar proteins
  2. XM_011537568.3XP_011535870.1  E3 ubiquitin-protein ligase SH3RF2 isoform X1

    See identical proteins and their annotated locations for XP_011535870.1

    Conserved Domains (4) summary
    cd11784
    Location:384438
    SH3_SH3RF2_3; Third Src Homology 3 domain of SH3 domain containing ring finger 2
    cd11929
    Location:128181
    SH3_SH3RF2_1; First Src Homology 3 domain of SH3 domain containing ring finger 2
    cd11932
    Location:191247
    SH3_SH3RF2_2; Second Src Homology 3 domain of SH3 domain containing ring finger 2
    cd16749
    Location:1155
    RING-HC_SH3RF2; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 2 (SH3RF2) and similar proteins
  3. XM_017009136.2XP_016864625.1  E3 ubiquitin-protein ligase SH3RF2 isoform X2

    UniProtKB/Swiss-Prot
    Q8TEC5, Q96LP8
    Related
    ENSP00000424497.1, ENST00000511217.1
    Conserved Domains (4) summary
    cd11784
    Location:384438
    SH3_SH3RF2_3; Third Src Homology 3 domain of SH3 domain containing ring finger 2
    cd11929
    Location:128181
    SH3_SH3RF2_1; First Src Homology 3 domain of SH3 domain containing ring finger 2
    cd11932
    Location:191247
    SH3_SH3RF2_2; Second Src Homology 3 domain of SH3 domain containing ring finger 2
    cd16749
    Location:1155
    RING-HC_SH3RF2; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 2 (SH3RF2) and similar proteins
  4. XM_011537567.3XP_011535869.1  E3 ubiquitin-protein ligase SH3RF2 isoform X1

    See identical proteins and their annotated locations for XP_011535869.1

    Conserved Domains (4) summary
    cd11784
    Location:384438
    SH3_SH3RF2_3; Third Src Homology 3 domain of SH3 domain containing ring finger 2
    cd11929
    Location:128181
    SH3_SH3RF2_1; First Src Homology 3 domain of SH3 domain containing ring finger 2
    cd11932
    Location:191247
    SH3_SH3RF2_2; Second Src Homology 3 domain of SH3 domain containing ring finger 2
    cd16749
    Location:1155
    RING-HC_SH3RF2; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 2 (SH3RF2) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    146470962..146597631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)