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PRELID2 PRELI domain containing 2 [ Homo sapiens (human) ]

Gene ID: 153768, updated on 5-Aug-2022

Summary

Official Symbol
PRELID2provided by HGNC
Official Full Name
PRELI domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28306
See related
Ensembl:ENSG00000186314 AllianceGenome:HGNC:28306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable phosphatidic acid transfer activity. Predicted to be involved in phospholipid transport. Predicted to be active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine (RPKM 2.0), colon (RPKM 1.4) and 17 other tissues See more
Orthologs
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Genomic context

See PRELID2 in Genome Data Viewer
Location:
5q32
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (145228985..145835342, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (146290613..146369665, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145135907..145214905, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 246 Neighboring gene nicotinamide phosphoribosyltransferase pseudogene 2 Neighboring gene argininosuccinate synthetase 1 pseudogene 10 Neighboring gene uncharacterized LOC105378211 Neighboring gene TRPC6 pseudogene 2 Neighboring gene CRISPRi-validated cis-regulatory element chr5.3602 Neighboring gene glutaredoxin and cysteine rich domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38376, MGC21644

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidic acid transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PRELI domain-containing protein 2
Names
CTC-806A22.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138492.6NP_612501.3  PRELI domain-containing protein 2 isoform c

    See identical proteins and their annotated locations for NP_612501.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, initiates translation at a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    AC011355, BC012033, DB266840
    Consensus CDS
    CCDS43377.1
    UniProtKB/Swiss-Prot
    Q8N945
    Related
    ENSP00000377965.2, ENST00000394450.6
    Conserved Domains (1) summary
    pfam04707
    Location:1144
    PRELI; PRELI-like family
  2. NM_182960.4NP_892005.1  PRELI domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_892005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC011355, AK095695, DB266840
    Consensus CDS
    CCDS34262.1
    UniProtKB/Swiss-Prot
    Q8N945, Q96EQ3
    Related
    ENSP00000335675.4, ENST00000334744.8
    Conserved Domains (1) summary
    pfam04707
    Location:16185
    PRELI; PRELI-like family
  3. NM_205846.3NP_995318.1  PRELI domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_995318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AC011355, BQ645893, DB266840
    Consensus CDS
    CCDS34261.1
    UniProtKB/Swiss-Prot
    Q8N945
    Related
    ENSP00000506938.1, ENST00000683046.1
    Conserved Domains (1) summary
    pfam04707
    Location:16173
    PRELI; PRELI-like family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    145228985..145835342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416830.1XP_047272786.1  PRELI domain-containing protein 2 isoform X5

  2. XM_047416832.1XP_047272788.1  PRELI domain-containing protein 2 isoform X6

  3. XM_047416828.1XP_047272784.1  PRELI domain-containing protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q96EQ3
  4. XM_017009133.2XP_016864622.1  PRELI domain-containing protein 2 isoform X6

  5. XM_017009130.2XP_016864619.1  PRELI domain-containing protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8N945, Q96EQ3
    Conserved Domains (1) summary
    pfam04707
    Location:16185
    PRELI; PRELI-like family
  6. XM_047416829.1XP_047272785.1  PRELI domain-containing protein 2 isoform X4

    Related
    ENSP00000422789.1, ENST00000511435.1
  7. XM_017009128.2XP_016864617.1  PRELI domain-containing protein 2 isoform X2

  8. XM_017009135.2XP_016864624.1  PRELI domain-containing protein 2 isoform X7

    Conserved Domains (1) summary
    pfam04707
    Location:16123
    PRELI; PRELI-like family
  9. XM_047416831.1XP_047272787.1  PRELI domain-containing protein 2 isoform X5

    Related
    ENSP00000424730.1, ENST00000505416.5
  10. XM_017009134.2XP_016864623.1  PRELI domain-containing protein 2 isoform X6

  11. XM_017009132.2XP_016864621.1  PRELI domain-containing protein 2 isoform X6

  12. XM_017009131.2XP_016864620.1  PRELI domain-containing protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8N945, Q96EQ3
    Conserved Domains (1) summary
    pfam04707
    Location:16185
    PRELI; PRELI-like family
  13. XM_017009127.2XP_016864616.1  PRELI domain-containing protein 2 isoform X1

RNA

  1. XR_007058586.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    146290613..146369665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)