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Hmox2 heme oxygenase 2 [ Mus musculus (house mouse) ]

Gene ID: 15369, updated on 18-Sep-2024

Summary

Official Symbol
Hmox2provided by MGI
Official Full Name
heme oxygenase 2provided by MGI
Primary source
MGI:MGI:109373
See related
Ensembl:ENSMUSG00000004070 AllianceGenome:MGI:109373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HO2; HO-2
Summary
Predicted to enable heme binding activity and heme oxygenase (decyclizing) activity. Predicted to be involved in several processes, including iron ion homeostasis; porphyrin-containing compound catabolic process; and response to hypoxia. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human HMOX2 (heme oxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 136.2), cerebellum adult (RPKM 25.6) and 26 other tissues See more
Orthologs
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Genomic context

See Hmox2 in Genome Data Viewer
Location:
16 A1; 16 2.46 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4544225..4584606)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4726361..4766742)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene STARR-seq mESC enhancer starr_39942 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4726231-4726340 Neighboring gene NmrA-like family domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_39943 Neighboring gene cell death inducing Trp53 target 1 Neighboring gene STARR-positive B cell enhancer ABC_E7425 Neighboring gene STARR-seq mESC enhancer starr_39945 Neighboring gene RIKEN cDNA 4930562C15 gene Neighboring gene predicted gene, 36513 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4878205-4878392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4879753-4879936 Neighboring gene UBA-like domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme oxygenase (decyclizing) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme oxygenase (decyclizing) activity ISO
Inferred from Sequence Orthology
more info
 
enables heme oxygenase (decyclizing) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in heme catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heme oxygenase 2
Names
heme oxygenase (decycling) 2
NP_001129538.1
NP_001343979.1
NP_001365928.1
NP_034573.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136066.2NP_001129538.1  heme oxygenase 2 isoform 1

    See identical proteins and their annotated locations for NP_001129538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK134536, BP769523, BY071995
    Consensus CDS
    CCDS27924.1
    UniProtKB/Swiss-Prot
    O70252, O70626
    UniProtKB/TrEMBL
    Q3U6W4, Q544R7
    Related
    ENSMUSP00000004172.9, ENSMUST00000004172.15
    Conserved Domains (1) summary
    pfam01126
    Location:30235
    Heme_oxygenase; Heme oxygenase
  2. NM_001357050.1NP_001343979.1  heme oxygenase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166903
    UniProtKB/TrEMBL
    Q3U6W4
    Conserved Domains (1) summary
    pfam01126
    Location:58263
    Heme_oxygenase; Heme oxygenase
  3. NM_001378999.1NP_001365928.1  heme oxygenase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166903
    UniProtKB/TrEMBL
    Q3U6W4
    Conserved Domains (1) summary
    pfam01126
    Location:49254
    Heme_oxygenase; Heme oxygenase
  4. NM_010443.2NP_034573.2  heme oxygenase 2 isoform 1

    See identical proteins and their annotated locations for NP_034573.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to transcript variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK134536, BP769523, CA465845
    Consensus CDS
    CCDS27924.1
    UniProtKB/Swiss-Prot
    O70252, O70626
    UniProtKB/TrEMBL
    Q3U6W4, Q544R7
    Related
    ENSMUSP00000112397.2, ENSMUST00000120232.8
    Conserved Domains (1) summary
    pfam01126
    Location:30235
    Heme_oxygenase; Heme oxygenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4544225..4584606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)