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ARSK arylsulfatase family member K [ Homo sapiens (human) ]

Gene ID: 153642, updated on 27-Nov-2021

Summary

Official Symbol
ARSKprovided by HGNC
Official Full Name
arylsulfatase family member Kprovided by HGNC
Primary source
HGNC:HGNC:25239
See related
Ensembl:ENSG00000164291 MIM:610011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSULF
Summary
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 2.9), ovary (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

See ARSK in Genome Data Viewer
Location:
5q15
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (95555101..95605102)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (94890805..94940806)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 81 member B Neighboring gene RTRAF pseudogene 2 Neighboring gene tetratricopeptide repeat domain 37 Neighboring gene RNA, U6 small nuclear 308, pseudogene Neighboring gene uncharacterized LOC112267933 Neighboring gene G protein-coupled receptor 150

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp313G1735

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arylsulfatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables arylsulfatase activity TAS
Traceable Author Statement
more info
PubMed 
enables glucuronate-2-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arylsulfatase K
Names
ASK
glucuronate-2-sulfatase
telethon sulfatase
NP_937793.1
XP_005271961.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198150.3NP_937793.1  arylsulfatase K precursor

    See identical proteins and their annotated locations for NP_937793.1

    Status: VALIDATED

    Source sequence(s)
    AC008547, AC090071, AY875939
    Consensus CDS
    CCDS4073.1
    UniProtKB/Swiss-Prot
    Q6UWY0
    Related
    ENSP00000369346.4, ENST00000380009.9
    Conserved Domains (1) summary
    cd16171
    Location:32447
    ARSK; arylsulfatase family, member K ....arylsulfatase k short ask flags precursor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    95555101..95605102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271904.4XP_005271961.1  arylsulfatase K isoform X1

    Conserved Domains (1) summary
    cl23718
    Location:1288
    ALP_like; alkaline phosphatases and sulfatases
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