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Hmgb3 high mobility group box 3 [ Mus musculus (house mouse) ]

Gene ID: 15354, updated on 4-Nov-2022

Summary

Official Symbol
Hmgb3provided by MGI
Official Full Name
high mobility group box 3provided by MGI
Primary source
MGI:MGI:1098219
See related
Ensembl:ENSMUSG00000015217 AllianceGenome:MGI:1098219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hmg4; Hmg2a
Summary
Enables DNA binding activity and RNA binding activity. Acts upstream of or within negative regulation of B cell differentiation and negative regulation of myeloid cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; ear; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in syndromic microphthalmia 13. Orthologous to human HMGB3 (high mobility group box 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 187.0), CNS E14 (RPKM 108.6) and 11 other tissues See more
Orthologs
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Genomic context

See Hmgb3 in Genome Data Viewer
Location:
X; X A7.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (70599523..70604279)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (71555917..71560673)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene CD99 antigen-like 2 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene G-protein-coupled receptor 50 Neighboring gene ribosomal protein L30, pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding, bending IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
high mobility group protein B3
Names
high mobility group protein 2a
high mobility group protein 4
high mobilty group protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293623.2NP_001280552.1  high mobility group protein B3 isoform 1

    See identical proteins and their annotated locations for NP_001280552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AL833776
    Consensus CDS
    CCDS30180.1
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    A0A6P5PBB9, A0A8C6IA30, Q544R9
    Related
    ENSMUSP00000086260.4, ENSMUST00000088874.10
    Conserved Domains (2) summary
    pfam00505
    Location:93160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:1378
    HMG_box_2; HMG-box domain
  2. NM_001293624.2NP_001280553.1  high mobility group protein B3 isoform 1

    See identical proteins and their annotated locations for NP_001280553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AL833776
    Consensus CDS
    CCDS30180.1
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    A0A6P5PBB9, A0A8C6IA30, Q544R9
    Related
    ENSMUSP00000110232.3, ENSMUST00000072699.13
    Conserved Domains (2) summary
    pfam00505
    Location:93160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:1378
    HMG_box_2; HMG-box domain
  3. NM_001293625.2NP_001280554.1  high mobility group protein B3 isoform 1

    See identical proteins and their annotated locations for NP_001280554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AL833776
    Consensus CDS
    CCDS30180.1
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    A0A6P5PBB9, A0A8C6IA30, Q544R9
    Related
    ENSMUSP00000015361.5, ENSMUST00000015361.11
    Conserved Domains (2) summary
    pfam00505
    Location:93160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:1378
    HMG_box_2; HMG-box domain
  4. NM_001411295.1NP_001398224.1  high mobility group protein B3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL833776
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    A0A6P5PBB9, A0A8C6IA30, Q544R9
  5. NM_001411296.1NP_001398225.1  high mobility group protein B3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL833776
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    A0A6P5PBB9, A0A8C6IA30, Q544R9
  6. NM_001411299.1NP_001398228.1  high mobility group protein B3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL833776
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    A0A6P5PBB9, A0A8C6IA30, Q544R9
  7. NM_001411300.1NP_001398229.1  high mobility group protein B3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL833776
  8. NM_001411301.1NP_001398230.1  high mobility group protein B3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL833776
  9. NM_001411302.1NP_001398231.1  high mobility group protein B3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL833776
  10. NM_001411303.1NP_001398232.1  high mobility group protein B3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL833776
  11. NM_008253.5NP_032279.1  high mobility group protein B3 isoform 1

    See identical proteins and their annotated locations for NP_032279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AL833776
    Consensus CDS
    CCDS30180.1
    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    A0A6P5PBB9, A0A8C6IA30, Q544R9
    Related
    ENSMUSP00000110229.3, ENSMUST00000114582.9
    Conserved Domains (2) summary
    pfam00505
    Location:93160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:1378
    HMG_box_2; HMG-box domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    70599523..70604279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527842.5XP_006527905.1  high mobility group protein B3 isoform X1

    See identical proteins and their annotated locations for XP_006527905.1

    UniProtKB/Swiss-Prot
    O54879
    UniProtKB/TrEMBL
    A0A6P5PBB9, A0A8C6IA30, Q544R9
    Conserved Domains (2) summary
    pfam00505
    Location:93160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:1378
    HMG_box_2; HMG-box domain