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ZMAT2 zinc finger matrin-type 2 [ Homo sapiens (human) ]

Gene ID: 153527, updated on 6-Sep-2022

Summary

Official Symbol
ZMAT2provided by HGNC
Official Full Name
zinc finger matrin-type 2provided by HGNC
Primary source
HGNC:HGNC:26433
See related
Ensembl:ENSG00000146007 MIM:619930; AllianceGenome:HGNC:26433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Snu23; Ptg-12
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 45.9), fat (RPKM 34.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZMAT2 in Genome Data Viewer
Location:
5q31.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (140700447..140706686)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (141225840..141232080)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (140080032..140086271)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene HARS1 and HARS2 bidirectional promoter region Neighboring gene histidyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC105378198 Neighboring gene vault RNA 1-1 Neighboring gene vault RNA 1-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger matrin-type protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144723.3NP_653324.1  zinc finger matrin-type protein 2

    See identical proteins and their annotated locations for NP_653324.1

    Status: VALIDATED

    Source sequence(s)
    AA071274, AC116353, AK055683
    Consensus CDS
    CCDS4239.1
    UniProtKB/Swiss-Prot
    Q96NC0
    Related
    ENSP00000274712.2, ENST00000274712.8
    Conserved Domains (2) summary
    smart00451
    Location:77108
    ZnF_U1; U1-like zinc finger
    pfam08648
    Location:178196
    DUF1777; Protein of unknown function (DUF1777)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    140700447..140706686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    141225840..141232080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)