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PLEKHG4B pleckstrin homology and RhoGEF domain containing G4B [ Homo sapiens (human) ]

Gene ID: 153478, updated on 9-Dec-2022

Summary

Official Symbol
PLEKHG4Bprovided by HGNC
Official Full Name
pleckstrin homology and RhoGEF domain containing G4Bprovided by HGNC
Primary source
HGNC:HGNC:29399
See related
Ensembl:ENSG00000153404 AllianceGenome:HGNC:29399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a large protein that contains a pleckstrin homology domain and may function as a guanine nucleotide exchange factor. [provided by RefSeq, May 2017]
Expression
Biased expression in thyroid (RPKM 1.2), testis (RPKM 0.6) and 8 other tissues See more
Orthologs
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Genomic context

See PLEKHG4B in Genome Data Viewer
Location:
5p15.33
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (92168..189966)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (82485..181320)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (92283..190081)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) pseudogene Neighboring gene Sharpr-MPRA regulatory region 259 Neighboring gene Sharpr-MPRA regulatory region 15179 Neighboring gene Sharpr-MPRA regulatory region 11960 Neighboring gene uncharacterized LOC124900929 Neighboring gene leucine rich repeat containing 14B Neighboring gene coiled-coil domain containing 127

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43173, KIAA1909

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology domain-containing family G member 4B
Names
PH domain-containing family G member 4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054915.1 RefSeqGene

    Range
    43154..140952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_052909.5NP_443141.4  pleckstrin homology domain-containing family G member 4B

    Status: REVIEWED

    Source sequence(s)
    AB067496, AC010443, AC021087, AK125163, BG325888, DR033854
    Consensus CDS
    CCDS34124.2
    UniProtKB/TrEMBL
    A0A1B0GW72
    Related
    ENSP00000490806.1, ENST00000637938.2
    Conserved Domains (3) summary
    cd13242
    Location:13321467
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    pfam00621
    Location:11651308
    RhoGEF; RhoGEF domain
    cl28033
    Location:186468
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    92168..189966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    82485..181320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)