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SRFBP1 serum response factor binding protein 1 [ Homo sapiens (human) ]

Gene ID: 153443, updated on 1-Jun-2020

Summary

Official Symbol
SRFBP1provided by HGNC
Official Full Name
serum response factor binding protein 1provided by HGNC
Primary source
HGNC:HGNC:26333
See related
Ensembl:ENSG00000151304 MIM:610479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P49; Rlb1; BUD22; STRAP; p49/STRAP
Expression
Ubiquitous expression in thyroid (RPKM 4.8), fat (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See SRFBP1 in Genome Data Viewer
Location:
5q23.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (121961975..122075624)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (121297656..121364295)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379149 Neighboring gene uncharacterized LOC105379148 Neighboring gene ferritin mitochondrial Neighboring gene ZNF474 antisense RNA 1 Neighboring gene zinc finger protein 474-like Neighboring gene lysyl oxidase Neighboring gene zinc finger protein 474 Neighboring gene synuclein alpha interacting protein Neighboring gene ancient vomeronasal 1 receptor pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25286

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Process Evidence Code Pubs
maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serum response factor-binding protein 1
Names
BUD22 homolog
SRF-dependent transcription regulation-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152546.3NP_689759.2  serum response factor-binding protein 1

    See identical proteins and their annotated locations for NP_689759.2

    Status: VALIDATED

    Source sequence(s)
    AC010255, AK058015, BC017102, BG193119
    Consensus CDS
    CCDS43354.1
    UniProtKB/Swiss-Prot
    Q8NEF9
    Related
    ENSP00000341324.4, ENST00000339397.5
    Conserved Domains (2) summary
    pfam09073
    Location:399428
    BUD22; BUD22
    cl25574
    Location:37285
    TOP2c; TopoisomeraseII

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    121961975..122075624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009111.2XP_016864600.2  serum response factor-binding protein 1 isoform X1

    Conserved Domains (1) summary
    cl25574
    Location:37285
    TOP2c; TopoisomeraseII
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