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SRFBP1 serum response factor binding protein 1 [ Homo sapiens (human) ]

Gene ID: 153443, updated on 17-Sep-2024

Summary

Official Symbol
SRFBP1provided by HGNC
Official Full Name
serum response factor binding protein 1provided by HGNC
Primary source
HGNC:HGNC:26333
See related
Ensembl:ENSG00000151304 MIM:610479; AllianceGenome:HGNC:26333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P49; Rlb1; BUD22; STRAP; p49/STRAP
Summary
Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of 90S preribosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 4.8), fat (RPKM 4.6) and 25 other tissues See more
Orthologs
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Genomic context

See SRFBP1 in Genome Data Viewer
Location:
5q23.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (121961975..122078935)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (122478734..122592980)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (121297670..121364328)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379149 Neighboring gene uncharacterized LOC105379148 Neighboring gene ferritin mitochondrial Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:121297323-121297861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:121412305-121412822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:121412823-121413340 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:121434535-121435734 Neighboring gene lysyl oxidase Neighboring gene Sharpr-MPRA regulatory region 13182 Neighboring gene ZNF474 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:121464631-121465830 Neighboring gene zinc finger protein 474 Neighboring gene zinc finger protein 475

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25286

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serum response factor-binding protein 1
Names
BUD22 homolog
SRF-dependent transcription regulation-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152546.3NP_689759.2  serum response factor-binding protein 1

    See identical proteins and their annotated locations for NP_689759.2

    Status: VALIDATED

    Source sequence(s)
    AC010255, AK058015, BC017102, BG193119
    Consensus CDS
    CCDS43354.1
    UniProtKB/Swiss-Prot
    Q5QFI2, Q8NEF9, Q96AH4, Q96DK2
    Related
    ENSP00000341324.4, ENST00000339397.5
    Conserved Domains (2) summary
    PTZ00108
    Location:37285
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam09073
    Location:355428
    BUD22

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    121961975..122078935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009111.3XP_016864600.2  serum response factor-binding protein 1 isoform X1

    Conserved Domains (1) summary
    cl25574
    Location:37285
    TOP2c; TopoisomeraseII

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    122478734..122592980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351798.1XP_054207773.1  serum response factor-binding protein 1 isoform X1