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TMEM161B transmembrane protein 161B [ Homo sapiens (human) ]

Gene ID: 153396, updated on 22-Sep-2022

Summary

Official Symbol
TMEM161Bprovided by HGNC
Official Full Name
transmembrane protein 161Bprovided by HGNC
Primary source
HGNC:HGNC:28483
See related
Ensembl:ENSG00000164180 AllianceGenome:HGNC:28483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLB3342; PRO1313
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in DNA integration. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.9), thyroid (RPKM 2.5) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM161B in Genome Data Viewer
Location:
5q14.3
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (88185570..88268845, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (88669371..88749895, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (87484133..87564662, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs267 Neighboring gene uncharacterized LOC105379070 Neighboring gene TMEM161B divergent transcript Neighboring gene RNA, 5S ribosomal pseudogene 187 Neighboring gene RPS3A pseudogene 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33214

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289007.2NP_001275936.1  transmembrane protein 161B isoform 1

    See identical proteins and their annotated locations for NP_001275936.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC010243, AK300893, AK301091, DW423642
    Consensus CDS
    CCDS75270.1
    UniProtKB/TrEMBL
    B7Z6T3, B7Z6X1, E9PCX5
    Related
    ENSP00000426354.1, ENST00000514135.5
    Conserved Domains (2) summary
    pfam10268
    Location:2425
    Tmemb_161AB; Predicted transmembrane protein 161AB
    cl21549
    Location:453494
    rve; Integrase core domain
  2. NM_001289008.2NP_001275937.1  transmembrane protein 161B isoform 3

    See identical proteins and their annotated locations for NP_001275937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region, initiates translation at a downstream start codon and contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC010243, AI570193, AK300893, BX390411, BX647345, DW423642
    Consensus CDS
    CCDS75269.1
    UniProtKB/TrEMBL
    B7Z6T3
    Related
    ENSP00000421498.1, ENST00000512429.5
    Conserved Domains (1) summary
    pfam10268
    Location:1473
    Tmemb_161AB; Predicted transmembrane protein 161AB
  3. NM_001349400.2NP_001336329.1  transmembrane protein 161B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
    Source sequence(s)
    AC010243, AI570193, AK300893, BC037287, BF103799, BX390411, BX647345, DC377704, DW423642
    Conserved Domains (1) summary
    pfam10268
    Location:1302
    Tmemb_161AB; Predicted transmembrane protein 161AB
  4. NM_001349402.2NP_001336331.1  transmembrane protein 161B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
    Source sequence(s)
    AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
    Conserved Domains (1) summary
    pfam10268
    Location:1302
    Tmemb_161AB; Predicted transmembrane protein 161AB
  5. NM_001349403.2NP_001336332.1  transmembrane protein 161B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
    Source sequence(s)
    AC010243, AI570193, AK300893, AK301091, BC037287, BX390411, BX647345, DW423642
    Conserved Domains (1) summary
    pfam10268
    Location:1302
    Tmemb_161AB; Predicted transmembrane protein 161AB
  6. NM_001349405.2NP_001336334.1  transmembrane protein 161B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
    Source sequence(s)
    AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
    Conserved Domains (1) summary
    pfam10268
    Location:1302
    Tmemb_161AB; Predicted transmembrane protein 161AB
  7. NM_001349407.2NP_001336336.1  transmembrane protein 161B isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has a novel 3' exon structure, resulting in a novel 3' coding region and a distinct 3' UTR compared to variant 1. It encodes isoform 5 which has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC010243, AK300893, AK301091, DW423642
    Conserved Domains (1) summary
    pfam10268
    Location:2438
    Tmemb_161AB; Predicted transmembrane protein 161AB
  8. NM_153354.5NP_699185.1  transmembrane protein 161B isoform 2

    See identical proteins and their annotated locations for NP_699185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a 3' terminal exon that extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
    Consensus CDS
    CCDS4065.1
    UniProtKB/Swiss-Prot
    Q6UWQ6, Q8NDZ6
    UniProtKB/TrEMBL
    B7Z6T3
    Related
    ENSP00000296595.6, ENST00000296595.11
    Conserved Domains (1) summary
    pfam10268
    Location:2484
    Tmemb_161AB; Predicted transmembrane protein 161AB

RNA

  1. NR_110266.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate internal exon and a 3' terminal exon that extends past a splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
    Related
    ENST00000511087.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    88185570..88268845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454373.2XP_024310141.1  transmembrane protein 161B isoform X8

    Conserved Domains (1) summary
    pfam10268
    Location:29465
    Tmemb_161AB; Predicted transmembrane protein 161AB
  2. XM_047416812.1XP_047272768.1  transmembrane protein 161B isoform X5

  3. XM_024454378.2XP_024310146.1  transmembrane protein 161B isoform X4

    Conserved Domains (1) summary
    pfam10268
    Location:1353
    Tmemb_161AB; Predicted transmembrane protein 161AB
  4. XM_024454375.2XP_024310143.1  transmembrane protein 161B isoform X1

    UniProtKB/TrEMBL
    B7Z6T3
    Conserved Domains (1) summary
    pfam10268
    Location:1473
    Tmemb_161AB; Predicted transmembrane protein 161AB
  5. XM_047416811.1XP_047272767.1  transmembrane protein 161B isoform X5

  6. XM_047416809.1XP_047272765.1  transmembrane protein 161B isoform X5

  7. XM_006714553.2XP_006714616.1  transmembrane protein 161B isoform X3

    See identical proteins and their annotated locations for XP_006714616.1

    Conserved Domains (1) summary
    pfam10268
    Location:2364
    Tmemb_161AB; Predicted transmembrane protein 161AB
  8. XM_047416808.1XP_047272764.1  transmembrane protein 161B isoform X1

    UniProtKB/TrEMBL
    B7Z6T3
  9. XM_024454376.2XP_024310144.1  transmembrane protein 161B isoform X2

    Conserved Domains (1) summary
    pfam10268
    Location:29391
    Tmemb_161AB; Predicted transmembrane protein 161AB
  10. XM_047416810.1XP_047272766.1  transmembrane protein 161B isoform X5

  11. XM_047416815.1XP_047272771.1  transmembrane protein 161B isoform X7

    Related
    ENSP00000425991.1, ENST00000511218.5
  12. XM_047416813.1XP_047272769.1  transmembrane protein 161B isoform X5

  13. XM_047416814.1XP_047272770.1  transmembrane protein 161B isoform X6

RNA

  1. XR_002959844.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    88669371..88749895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)