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CREBRF CREB3 regulatory factor [ Homo sapiens (human) ]

Gene ID: 153222, updated on 12-Oct-2019

Summary

Official Symbol
CREBRFprovided by HGNC
Official Full Name
CREB3 regulatory factorprovided by HGNC
Primary source
HGNC:HGNC:24050
See related
Ensembl:ENSG00000164463 MIM:617109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRF; C5orf41
Expression
Ubiquitous expression in thyroid (RPKM 12.2), bone marrow (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See CREBRF in Genome Data Viewer
Location:
5q35.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (173056349..173139284)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172483355..172566291)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5956 Neighboring gene ATPase H+ transporting V0 subunit e1 Neighboring gene small nucleolar RNA, H/ACA box 74B Neighboring gene cell division cycle 42 pseudogene 5 Neighboring gene BCL2 interacting protein 1 Neighboring gene ribosomal protein L7a pseudogene 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp313F2319, DKFZp686G2059

Gene Ontology Provided by GOA

Process Evidence Code Pubs
endoplasmic reticulum unfolded protein response TAS
Traceable Author Statement
more info
 
maternal behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glucocorticoid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of prolactin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nuclear body IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CREB3 regulatory factor
Names
UPF0474 protein C5orf41
adult retina protein
luman recruitment factor
luman-recruiting factor
luman/CREB3 recruitment factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168393.2NP_001161865.1  CREB3 regulatory factor isoform 2

    See identical proteins and their annotated locations for NP_001161865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR and coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Both variant 2 and variant 3 encode the same isoform (2).
    Source sequence(s)
    BX647768
    Consensus CDS
    CCDS54948.1
    UniProtKB/Swiss-Prot
    Q8IUR6
    Related
    ENSP00000431107.1, ENST00000522692.5
  2. NM_001168394.2NP_001161866.1  CREB3 regulatory factor isoform 2

    See identical proteins and their annotated locations for NP_001161866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Both variant 2 and variant 3 encode the same isoform (2).
    Source sequence(s)
    AY174896, BX647768
    Consensus CDS
    CCDS54948.1
    UniProtKB/Swiss-Prot
    Q8IUR6
    Related
    ENSP00000428290.1, ENST00000520420.5
  3. NM_153607.3NP_705835.2  CREB3 regulatory factor isoform 1

    See identical proteins and their annotated locations for NP_705835.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008378, AY139008, BX647768
    Consensus CDS
    CCDS34293.1
    UniProtKB/Swiss-Prot
    Q8IUR6
    Related
    ENSP00000296953.2, ENST00000296953.6
    Conserved Domains (1) summary
    cd14809
    Location:525563
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    173056349..173139284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265821.3XP_005265878.1  CREB3 regulatory factor isoform X2

    See identical proteins and their annotated locations for XP_005265878.1

    Conserved Domains (1) summary
    cd14809
    Location:517555
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains
  2. XM_011534442.1XP_011532744.1  CREB3 regulatory factor isoform X2

    See identical proteins and their annotated locations for XP_011532744.1

    Conserved Domains (1) summary
    cd14809
    Location:517555
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains
  3. XM_006714822.4XP_006714885.1  CREB3 regulatory factor isoform X1

    See identical proteins and their annotated locations for XP_006714885.1

    UniProtKB/Swiss-Prot
    Q8IUR6
    Conserved Domains (1) summary
    cd14809
    Location:525563
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains
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