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SPINK13 serine peptidase inhibitor Kazal type 13 [ Homo sapiens (human) ]

Gene ID: 153218, updated on 24-Nov-2020

Summary

Official Symbol
SPINK13provided by HGNC
Official Full Name
serine peptidase inhibitor Kazal type 13provided by HGNC
Primary source
HGNC:HGNC:27200
See related
Ensembl:ENSG00000214510 MIM:615205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LiESP6; SPINK5L3; HESPINTOR; HBVDNAPTP1
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See SPINK13 in Genome Data Viewer
Location:
5q32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (148268794..148286255)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (147648423..147665773)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CAGE-defined high expression enhancer downstream of SPINK6 Neighboring gene MARCO like Neighboring gene uncharacterized LOC102546294 Neighboring gene piggyBac transposable element derived 4 pseudogene 3 Neighboring gene serine peptidase inhibitor Kazal type 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Homology

Clone Names

  • MGC149260

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of acrosome reaction ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease inhibitor Kazal-type 13
Names
Hepatitis B Virus (HBV) DNA polymerase transactivated protein 1
hepatitis B virus DNA polymerase transactivated human serine protease inhibitor
hepatitis B virus DNA polymerase transactivated serine protease inhibitor
serine peptidase inhibitor, Kazal type 13 (putative)
serine protease inhibitor Kazal-type 5-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040129.3NP_001035218.1  serine protease inhibitor Kazal-type 13 precursor

    See identical proteins and their annotated locations for NP_001035218.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC011346, BC128164
    Consensus CDS
    CCDS43383.1
    UniProtKB/Swiss-Prot
    Q1W4C9
    Related
    ENSP00000381468.4, ENST00000398450.5
    Conserved Domains (1) summary
    cd00104
    Location:5393
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RNA

  1. NR_138538.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC011346, BC128163
    Related
    ENST00000511106.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    148268794..148286255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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