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Hk2 hexokinase 2 [ Mus musculus (house mouse) ]

Gene ID: 15277, updated on 8-Jan-2023

Summary

Official Symbol
Hk2provided by MGI
Official Full Name
hexokinase 2provided by MGI
Primary source
MGI:MGI:1315197
See related
Ensembl:ENSMUSG00000000628 AllianceGenome:MGI:1315197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HKII
Summary
Enables hexokinase activity. Involved in negative regulation of mitochondrial membrane permeability and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within several processes, including carbohydrate phosphorylation; cellular response to leukemia inhibitory factor; and regulation of glucose import. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (hexokinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 28.6), genital fat pad adult (RPKM 13.1) and 16 other tissues See more
Orthologs
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Genomic context

See Hk2 in Genome Data Viewer
Location:
6 C3; 6 35.94 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (82702004..82751435, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (82725025..82774454, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32534 Neighboring gene predicted gene, 32480 Neighboring gene predicted gene, 38843 Neighboring gene predicted gene, 32591

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables glucose binding ISO
Inferred from Sequence Orthology
more info
 
enables hexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hexokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hexokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic mitochondrial changes IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within apoptotic mitochondrial changes ISO
Inferred from Sequence Orthology
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within carbohydrate phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in establishment of protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in maintenance of protein location in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitochondrial membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hexokinase-2
Names
HK II
hexokinase type II
NP_038848.1
XP_017176890.1
XP_036021773.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013820.4NP_038848.1  hexokinase-2

    See identical proteins and their annotated locations for NP_038848.1

    Status: VALIDATED

    Source sequence(s)
    AC116811
    Consensus CDS
    CCDS20263.1
    UniProtKB/Swiss-Prot
    O08528
    Related
    ENSMUSP00000000642.5, ENSMUST00000000642.11
    Conserved Domains (3) summary
    PTZ00107
    Location:12460
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:21219
    Hexokinase_1; Hexokinase
    pfam03727
    Location:673907
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    82702004..82751435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321401.3XP_017176890.1  hexokinase-2 isoform X1

    Conserved Domains (2) summary
    pfam00349
    Location:365561
    Hexokinase_1
    pfam03727
    Location:567801
    Hexokinase_2
  2. XM_036165880.1XP_036021773.1  hexokinase-2 isoform X1

    Conserved Domains (2) summary
    pfam00349
    Location:365561
    Hexokinase_1
    pfam03727
    Location:567801
    Hexokinase_2