Format

Send to:

Choose Destination

H2ax H2A.X variant histone [ Mus musculus (house mouse) ]

Gene ID: 15270, updated on 14-Sep-2021

Summary

Official Symbol
H2axprovided by MGI
Official Full Name
H2A.X variant histoneprovided by MGI
Primary source
MGI:MGI:102688
See related
Ensembl:ENSMUSG00000049932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H2A.; H2af; H2A.X; H2afx; Hist5-; gammaH; AW228881; Hist5-2ax; gammaH2ax
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See H2ax in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44246012..44247374)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44334715..44336077)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (44142798..44144160)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene histone H4 transcription factor Neighboring gene C2 calcium-dependent domain containing 2-like Neighboring gene dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) Neighboring gene hydroxymethylbilane synthase Neighboring gene VPS11, CORVET/HOPS core subunit

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in XY body IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H2AX
Names
H2A histone family, member X
H2a/x
histone 5 protein 2ax
histone H2A.x

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010436.2NP_034566.1  histone H2AX

    See identical proteins and their annotated locations for NP_034566.1

    Status: REVIEWED

    Source sequence(s)
    BC010336
    Consensus CDS
    CCDS23105.1
    UniProtKB/Swiss-Prot
    P27661
    Related
    ENSMUSP00000051432.3, ENSMUST00000052686.4
    Conserved Domains (1) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44246012..44247374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center