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MGAT4D MGAT4 family member D [ Homo sapiens (human) ]

Gene ID: 152586, updated on 10-Oct-2024

Summary

Official Symbol
MGAT4Dprovided by HGNC
Official Full Name
MGAT4 family member Dprovided by HGNC
Primary source
HGNC:HGNC:43619
See related
Ensembl:ENSG00000205301 MIM:610310; AllianceGenome:HGNC:43619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GnT1IP
Summary
Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 7.0) See more
Orthologs
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Genomic context

See MGAT4D in Genome Data Viewer
Location:
4q31.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (140442262..140498293, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (143762026..143818003, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (141363416..141419447, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene short coiled-coil protein Neighboring gene SCOC antisense RNA 1 Neighboring gene OCT4 hESC enhancer GRCh37_chr4:141294483-141294984 Neighboring gene ribosomal protein L14 pseudogene 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:141334799-141335364 Neighboring gene calmegin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:141418967-141419468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:141419469-141419968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15711 Neighboring gene ELMO domain containing 2 Neighboring gene uncoupling protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association with select biomarker traits in the Framingham Heart Study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC43429

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
Names
GlcNAcT-I Inhibitory Protein
N-acetylglucosaminyltransferase MGAT1 inhibitory protein
glycosyltransferase 54 domain containing 1
glycosyltransferase 54 domain-containing protein
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase family, member D
NP_001264282.1
XP_011529952.1
XP_011529953.1
XP_011529954.1
XP_011529955.1
XP_011529956.1
XP_011529958.1
XP_011529959.1
XP_011529960.1
XP_011529961.1
XP_011529963.1
XP_011529964.1
XP_011529966.1
XP_011529967.1
XP_047305604.1
XP_054204975.1
XP_054204976.1
XP_054204977.1
XP_054204978.1
XP_054204979.1
XP_054204980.1
XP_054204981.1
XP_054204982.1
XP_054204983.1
XP_054204984.1
XP_054204985.1
XP_054204986.1
XP_054204987.1
XP_054204988.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277353.2NP_001264282.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D precursor

    See identical proteins and their annotated locations for NP_001264282.1

    Status: VALIDATED

    Source sequence(s)
    AC093671, BI826002, BI828214, DB444046, DB462368
    Consensus CDS
    CCDS64066.1
    UniProtKB/Swiss-Prot
    A6NG13
    UniProtKB/TrEMBL
    D6RH02
    Related
    ENSP00000421185.1, ENST00000511113.6
    Conserved Domains (1) summary
    pfam04666
    Location:96372
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    140442262..140498293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531665.4XP_011529967.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X10

    See identical proteins and their annotated locations for XP_011529967.1

    Conserved Domains (1) summary
    pfam04666
    Location:1186
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  2. XM_011531658.4XP_011529960.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X6

    Conserved Domains (1) summary
    pfam04666
    Location:30273
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  3. XM_011531656.4XP_011529958.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X4

    UniProtKB/TrEMBL
    D6RH02
    Conserved Domains (1) summary
    pfam04666
    Location:85326
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  4. XM_011531654.4XP_011529956.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X3

    UniProtKB/TrEMBL
    D6RH02
    Conserved Domains (1) summary
    pfam04666
    Location:96353
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  5. XM_011531650.4XP_011529952.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X1

    UniProtKB/TrEMBL
    D6RH02
    Conserved Domains (1) summary
    pfam04666
    Location:96362
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  6. XM_011531653.4XP_011529955.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X2

    See identical proteins and their annotated locations for XP_011529955.1

    UniProtKB/TrEMBL
    D6RH02
    Conserved Domains (1) summary
    pfam04666
    Location:80356
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  7. XM_011531652.3XP_011529954.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X2

    See identical proteins and their annotated locations for XP_011529954.1

    UniProtKB/TrEMBL
    D6RH02
    Conserved Domains (1) summary
    pfam04666
    Location:80356
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  8. XM_011531651.3XP_011529953.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X2

    See identical proteins and their annotated locations for XP_011529953.1

    UniProtKB/TrEMBL
    D6RH02
    Conserved Domains (1) summary
    pfam04666
    Location:80356
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  9. XM_011531664.3XP_011529966.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X10

    See identical proteins and their annotated locations for XP_011529966.1

    Conserved Domains (1) summary
    pfam04666
    Location:1186
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  10. XM_011531657.4XP_011529959.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X5

    UniProtKB/TrEMBL
    D6RH02
    Conserved Domains (1) summary
    pfam04666
    Location:48324
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  11. XM_047449648.1XP_047305604.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X10

  12. XM_011531659.3XP_011529961.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X7

    Conserved Domains (1) summary
    pfam04666
    Location:96254
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  13. XM_011531661.3XP_011529963.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X8

    Conserved Domains (1) summary
    pfam04666
    Location:96218
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  14. XM_011531662.3XP_011529964.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X9

    Conserved Domains (1) summary
    pfam04666
    Location:96191
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

RNA

  1. XR_938697.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    143762026..143818003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349012.1XP_054204987.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X10

  2. XM_054349007.1XP_054204982.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X6

  3. XM_054349005.1XP_054204980.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X4

  4. XM_054349004.1XP_054204979.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X3

  5. XM_054349000.1XP_054204975.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X1

  6. XM_054349003.1XP_054204978.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X2

  7. XM_054349002.1XP_054204977.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X2

  8. XM_054349001.1XP_054204976.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X2

  9. XM_054349011.1XP_054204986.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X10

  10. XM_054349006.1XP_054204981.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X5

  11. XM_054349013.1XP_054204988.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X10

  12. XM_054349008.1XP_054204983.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X7

  13. XM_054349009.1XP_054204984.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X8

  14. XM_054349010.1XP_054204985.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X9

RNA

  1. XR_008486929.1 RNA Sequence

  2. XR_008486930.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001034840.1: Suppressed sequence

    Description
    NM_001034840.1: This RefSeq was permanently suppressed because it is a partial sequence.