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SHISA3 shisa family member 3 [ Homo sapiens (human) ]

Gene ID: 152573, updated on 12-Oct-2019

Summary

Official Symbol
SHISA3provided by HGNC
Official Full Name
shisa family member 3provided by HGNC
Primary source
HGNC:HGNC:25159
See related
Ensembl:ENSG00000178343 MIM:617325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hShisa3
Summary
This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017]
Expression
Biased expression in kidney (RPKM 14.3), lymph node (RPKM 4.2) and 12 other tissues See more
Orthologs

Genomic context

See SHISA3 in Genome Data Viewer
Location:
4p13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (42397488..42402487)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (42399856..42404504)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374428 Neighboring gene Sharpr-MPRA regulatory region 13490 Neighboring gene Sharpr-MPRA regulatory region 6384 Neighboring gene ATPase phospholipid transporting 8A1 Neighboring gene ribosomal protein S7 pseudogene 7 Neighboring gene cyclin L2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein shisa-3 homolog
Names
shisa homolog 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080505.3NP_001073974.1  protein shisa-3 homolog precursor

    See identical proteins and their annotated locations for NP_001073974.1

    Status: REVIEWED

    Source sequence(s)
    AA131240, AC024022, AC084010
    Consensus CDS
    CCDS33979.1
    UniProtKB/Swiss-Prot
    A0PJX4
    Related
    ENSP00000326445.4, ENST00000319234.5
    Conserved Domains (1) summary
    pfam13908
    Location:25161
    Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    42397488..42402487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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