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SH3D19 SH3 domain containing 19 [ Homo sapiens (human) ]

Gene ID: 152503, updated on 18-Aug-2020

Summary

Official Symbol
SH3D19provided by HGNC
Official Full Name
SH3 domain containing 19provided by HGNC
Primary source
HGNC:HGNC:30418
See related
Ensembl:ENSG00000109686 MIM:608674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EBP; EVE1; Kryn; Eve-1; SH3P19
Summary
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in fat (RPKM 43.0), gall bladder (RPKM 40.6) and 23 other tissues See more
Orthologs

Genomic context

See SH3D19 in Genome Data Viewer
Location:
4q31.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (151120281..151325665, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (152041433..152246797, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986196 Neighboring gene small nucleolar RNA, C/D box U73B Neighboring gene small nucleolar RNA, C/D box 73A Neighboring gene ribosomal protein S3A Neighboring gene uncharacterized LOC105377485 Neighboring gene RNA, U6 small nuclear 1282, pseudogene Neighboring gene serine protease 48 Neighboring gene FAM160A1 divergent transcript Neighboring gene family with sequence similarity 160 member A1 Neighboring gene RN7SK pseudogene 35

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105136, MGC118910, MGC118911, MGC118912, MGC118913

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of membrane protein ectodomain proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SH3 domain-containing protein 19
Names
ADAM-binding protein Eve-1
EEN-binding protein
SH3 domain protein D19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029721.1 RefSeqGene

    Range
    5001..111228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009555.4NP_001009555.3  SH3 domain-containing protein 19 isoform 1

    See identical proteins and their annotated locations for NP_001009555.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Eve-1a).
    Source sequence(s)
    AC095055, AW263019, BC032404, BM670337, BM831166, BX647422, CD675494, DB277036, DB278138
    Consensus CDS
    CCDS34077.2
    UniProtKB/Swiss-Prot
    Q5HYK7
    Related
    ENSP00000302913.4, ENST00000304527.8
    Conserved Domains (6) summary
    cd11814
    Location:419468
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11815
    Location:499550
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:575625
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:665714
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:734783
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl26464
    Location:29369
    Atrophin-1; Atrophin-1 family
  2. NM_001128923.2NP_001122395.1  SH3 domain-containing protein 19 isoform 2

    See identical proteins and their annotated locations for NP_001122395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as Eve-1b) missing an internal protein segment compared to isoform 1. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC095055, AW263019, BC032404, BM670337, BM831166, CD675494, DB277036
    Consensus CDS
    CCDS47144.1
    UniProtKB/Swiss-Prot
    Q5HYK7
    Related
    ENSP00000387030.4, ENST00000409598.8
    Conserved Domains (6) summary
    cd11815
    Location:476527
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:552602
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:642691
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:711760
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl17036
    Location:415445
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:29369
    Atrophin-1; Atrophin-1 family
  3. NM_001128924.2NP_001122396.1  SH3 domain-containing protein 19 isoform 3

    See identical proteins and their annotated locations for NP_001122396.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon in the 5' region compared to variant 1. This results in a shorter isoform (3) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AW263019, BC032404, BC108893, BM670337, BM831166, CD675494
    Consensus CDS
    CCDS47143.1
    UniProtKB/Swiss-Prot
    Q5HYK7
    Related
    ENSP00000415694.1, ENST00000427414.2
    Conserved Domains (5) summary
    cd11815
    Location:440491
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:516566
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:606655
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:675724
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl17036
    Location:379409
    SH3; Src Homology 3 domain superfamily
  4. NM_001243349.2NP_001230278.1  SH3 domain-containing protein 19 isoform 2

    See identical proteins and their annotated locations for NP_001230278.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal non-coding exon, and lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as Eve-1b) missing an internal protein segment compared to isoform 1. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AK294476, BC045742, BF109395, CF541231
    Consensus CDS
    CCDS47144.1
    UniProtKB/Swiss-Prot
    Q5HYK7
    Related
    ENSP00000423449.1, ENST00000514152.5
    Conserved Domains (6) summary
    cd11815
    Location:476527
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:552602
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:642691
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:711760
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl17036
    Location:415445
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:29369
    Atrophin-1; Atrophin-1 family
  5. NM_001378121.1NP_001365050.1  SH3 domain-containing protein 19 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC095055, AC104819
  6. NM_001378122.1NP_001365051.1  SH3 domain-containing protein 19 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC095055, AC104819
    Related
    ENSP00000488951.1, ENST00000604030.6
  7. NM_001378123.1NP_001365052.1  SH3 domain-containing protein 19 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC095055
    Related
    ENSP00000499127.1, ENST00000652233.1
  8. NM_001378124.1NP_001365053.1  SH3 domain-containing protein 19 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC095055
  9. NM_001378126.1NP_001365055.1  SH3 domain-containing protein 19 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC095055
    Related
    ENSP00000386848.2, ENST00000409252.6
  10. NM_001378127.1NP_001365056.1  SH3 domain-containing protein 19 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC095055
  11. NM_001378128.1NP_001365057.1  SH3 domain-containing protein 19 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC095055, AC104819
  12. NM_001378129.1NP_001365058.1  SH3 domain-containing protein 19 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC095055
  13. NM_001378130.1NP_001365059.1  SH3 domain-containing protein 19 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC095055
  14. NM_001378131.1NP_001365060.1  SH3 domain-containing protein 19 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC095055, AC104819

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    151120281..151325665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531649.2XP_011529951.2  SH3 domain-containing protein 19 isoform X7

    Conserved Domains (6) summary
    cd11815
    Location:723774
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:799849
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:889938
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:9581007
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl17036
    Location:662692
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:54524
    Atrophin-1; Atrophin-1 family
  2. XM_011531647.2XP_011529949.2  SH3 domain-containing protein 19 isoform X5

    Conserved Domains (6) summary
    cd11814
    Location:666715
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11815
    Location:746797
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:822872
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:912961
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:9811030
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl26464
    Location:54524
    Atrophin-1; Atrophin-1 family
  3. XM_024453902.1XP_024309670.1  SH3 domain-containing protein 19 isoform X3

    Conserved Domains (6) summary
    cd11815
    Location:759810
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:835885
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:925974
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:9941043
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl17036
    Location:698728
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:184652
    Atrophin-1; Atrophin-1 family
  4. XM_024453900.1XP_024309668.1  SH3 domain-containing protein 19 isoform X1

    Conserved Domains (6) summary
    cd11814
    Location:702751
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11815
    Location:782833
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:858908
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:948997
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:10171066
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl26464
    Location:184652
    Atrophin-1; Atrophin-1 family
  5. XM_017007779.2XP_016863268.1  SH3 domain-containing protein 19 isoform X9

    UniProtKB/Swiss-Prot
    Q5HYK7
    Conserved Domains (5) summary
    cd11815
    Location:440491
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:516566
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:606655
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:675724
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl17036
    Location:379409
    SH3; Src Homology 3 domain superfamily
  6. XM_024453904.1XP_024309672.1  SH3 domain-containing protein 19 isoform X6

    Conserved Domains (6) summary
    cd11814
    Location:643692
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11815
    Location:723774
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:799849
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:889938
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:9581007
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl26464
    Location:125593
    Atrophin-1; Atrophin-1 family
  7. XM_005262767.3XP_005262824.1  SH3 domain-containing protein 19 isoform X2

    See identical proteins and their annotated locations for XP_005262824.1

    UniProtKB/Swiss-Prot
    Q5HYK7
    Conserved Domains (6) summary
    cd11814
    Location:419468
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11815
    Location:499550
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:575625
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:665714
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:734783
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl26464
    Location:29369
    Atrophin-1; Atrophin-1 family
  8. XM_011531646.2XP_011529948.1  SH3 domain-containing protein 19 isoform X2

    See identical proteins and their annotated locations for XP_011529948.1

    UniProtKB/Swiss-Prot
    Q5HYK7
    Conserved Domains (6) summary
    cd11814
    Location:419468
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11815
    Location:499550
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:575625
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:665714
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:734783
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl26464
    Location:29369
    Atrophin-1; Atrophin-1 family
  9. XM_017007778.1XP_016863267.1  SH3 domain-containing protein 19 isoform X8

  10. XM_011531648.1XP_011529950.1  SH3 domain-containing protein 19 isoform X6

    Conserved Domains (6) summary
    cd11814
    Location:643692
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11815
    Location:723774
    SH3_Eve1_2; Second Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:799849
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11817
    Location:889938
    SH3_Eve1_4; Fourth Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:9581007
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl26464
    Location:125593
    Atrophin-1; Atrophin-1 family
  11. XM_024453907.1XP_024309675.1  SH3 domain-containing protein 19 isoform X11

    Conserved Domains (1) summary
    cl26464
    Location:184482
    Atrophin-1; Atrophin-1 family
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