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Hhex hematopoietically expressed homeobox [ Mus musculus (house mouse) ]

Gene ID: 15242, updated on 12-Aug-2018
Official Symbol
Hhexprovided by MGI
Official Full Name
hematopoietically expressed homeoboxprovided by MGI
Primary source
MGI:MGI:96086
See related
Ensembl:ENSMUSG00000024986 Vega:OTTMUSG00000021162
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hex; Prh; Hex1; Prhx; Hhex-rs2
Expression
Biased expression in adrenal adult (RPKM 160.1), liver adult (RPKM 39.6) and 5 other tissues See more
Orthologs
See Hhex in Genome Data Viewer
Location:
19 C2; 19 32.28 cM
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (37434841..37440731)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (37509331..37515221)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene kinesin family member 11 Neighboring gene mortality factor 4 like 1 pseudogene Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene RIKEN cDNA 1700122C19 gene Neighboring gene predicted gene, 32294

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding, bending ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
HMG box domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic initiation factor 4E binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA conformation change ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
common bile duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
gall bladder development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hepatic duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hepatoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hepatocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
interkinetic nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid leukocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
poly(A)+ mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
primary lung bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
primitive streak formation IGI
Inferred from Genetic Interaction
more info
PubMed 
primitive streak formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
hematopoietically-expressed homeobox protein Hhex
Names
hematopoietically expressed homeobox, related sequence 2
homeobox protein HEX
homeobox protein PRH
mHex

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008245.3NP_032271.1  hematopoietically-expressed homeobox protein Hhex

    See identical proteins and their annotated locations for NP_032271.1

    Status: PROVISIONAL

    Source sequence(s)
    AK033664
    Consensus CDS
    CCDS29778.1
    UniProtKB/Swiss-Prot
    P43120
    Related
    ENSMUSP00000025944.2, OTTMUSP00000023363, ENSMUST00000025944.8, OTTMUST00000050138
    Conserved Domains (1) summary
    pfam00046
    Location:144194
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    37434841..37440731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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