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IGSF11 immunoglobulin superfamily member 11 [ Homo sapiens (human) ]

Gene ID: 152404, updated on 7-Jun-2020

Summary

Official Symbol
IGSF11provided by HGNC
Official Full Name
immunoglobulin superfamily member 11provided by HGNC
Primary source
HGNC:HGNC:16669
See related
Ensembl:ENSG00000144847 MIM:608351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT119; VSIG3; Igsf13; BT-IgSF; CXADRL1
Summary
IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).[supplied by OMIM, Apr 2005]
Expression
Biased expression in testis (RPKM 12.0), brain (RPKM 8.3) and 4 other tissues See more
Orthologs

Genomic context

See IGSF11 in Genome Data Viewer
Location:
3q13.32
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (118900557..119146064, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (118619477..118864915, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374060 Neighboring gene uncharacterized LOC107983969 Neighboring gene uncharacterized LOC105374059 Neighboring gene IGSF11 antisense RNA 1 Neighboring gene testis expressed 55 Neighboring gene uroplakin 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene network analysis in a pediatric cohort identifies novel lung function genes.
NHGRI GWA Catalog
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC35227

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
homophilic cell adhesion via plasma membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of protein location IEA
Inferred from Electronic Annotation
more info
 
positive regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mini excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
immunoglobulin superfamily member 11
Names
CXADR like 1
V-set and immunoglobulin domain containing 3
V-set and immunoglobulin domain-containing protein 3
brain and testis-specific immunoglobin superfamily protein
brain and testis-specific immunoglobulin superfamily protein
cancer/testis antigen 119

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015887.3NP_001015887.1  immunoglobulin superfamily member 11 isoform b precursor

    See identical proteins and their annotated locations for NP_001015887.1

    Status: VALIDATED

    Source sequence(s)
    AB071618, AC007023, AC068984, AL834256, AY358141
    Consensus CDS
    CCDS46891.1
    UniProtKB/Swiss-Prot
    Q5DX21
    Related
    ENSP00000377370.2, ENST00000393775.7
    Conserved Domains (3) summary
    smart00410
    Location:29124
    IG_like; Immunoglobulin like
    pfam07686
    Location:27141
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:156223
    Ig; Immunoglobulin domain
  2. NM_001353318.2NP_001340247.1  immunoglobulin superfamily member 11 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC007023, AC068984, AL834256
    Conserved Domains (2) summary
    pfam07686
    Location:77191
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:208269
    Ig_3; Immunoglobulin domain
  3. NM_001353319.2NP_001340248.1  immunoglobulin superfamily member 11 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC007023, AC068984, AL834256
    Conserved Domains (2) summary
    pfam07686
    Location:77191
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:208269
    Ig_3; Immunoglobulin domain
  4. NM_001353320.2NP_001340249.1  immunoglobulin superfamily member 11 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC007023, AC068984, AC083800, AK292387, AL834256
    Consensus CDS
    CCDS2983.1
    Related
    ENSP00000406092.2, ENST00000425327.6
    Conserved Domains (2) summary
    pfam07686
    Location:26140
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:157218
    Ig_3; Immunoglobulin domain
  5. NM_001353321.2NP_001340250.1  immunoglobulin superfamily member 11 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC007023, AC068984, AL834256
    Consensus CDS
    CCDS87124.1
    Related
    ENSP00000420486.1, ENST00000489689.5
    Conserved Domains (2) summary
    pfam07686
    Location:27141
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:158207
    Ig_3; Immunoglobulin domain
  6. NM_001353322.2NP_001340251.1  immunoglobulin superfamily member 11 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AA292896, AB071618, AC068984, AC083800, AL834256, BI828564
    Consensus CDS
    CCDS87125.1
    Related
    ENSP00000401240.2, ENST00000441144.6
    Conserved Domains (2) summary
    pfam07686
    Location:26140
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:157206
    Ig_3; Immunoglobulin domain
  7. NM_001353323.2NP_001340252.1  immunoglobulin superfamily member 11 isoform g precursor

    Status: VALIDATED

    Source sequence(s)
    AC007023, AC068984, AL834256
    Consensus CDS
    CCDS87123.1
    Related
    ENSP00000417413.1, ENST00000491903.1
    Conserved Domains (2) summary
    pfam07686
    Location:27141
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:158219
    Ig_3; Immunoglobulin domain
  8. NM_001353324.2NP_001340253.1  immunoglobulin superfamily member 11 isoform h precursor

    Status: VALIDATED

    Source sequence(s)
    AC007023, AC068984, AL834256
    Conserved Domains (2) summary
    pfam07686
    Location:27141
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:158211
    Ig_3; Immunoglobulin domain
  9. NM_001353325.2NP_001340254.1  immunoglobulin superfamily member 11 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC007023, AC068984, AL834256
    Conserved Domains (2) summary
    pfam13927
    Location:99160
    Ig_3; Immunoglobulin domain
    cl11960
    Location:878
    Ig; Immunoglobulin domain
  10. NM_001353326.2NP_001340255.1  immunoglobulin superfamily member 11 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC007023, AC068984, AL834256
    Conserved Domains (2) summary
    pfam13927
    Location:99148
    Ig_3; Immunoglobulin domain
    cl11960
    Location:878
    Ig; Immunoglobulin domain
  11. NM_152538.4NP_689751.2  immunoglobulin superfamily member 11 isoform a precursor

    See identical proteins and their annotated locations for NP_689751.2

    Status: VALIDATED

    Source sequence(s)
    AA292896, AB071618, AC068984, AC083800, AL834256, BI828564
    Consensus CDS
    CCDS2983.1
    UniProtKB/Swiss-Prot
    Q5DX21
    Conserved Domains (2) summary
    pfam07686
    Location:26140
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:157218
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    118900557..119146064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512465.2XP_011510767.1  immunoglobulin superfamily member 11 isoform X1

    See identical proteins and their annotated locations for XP_011510767.1

    Conserved Domains (3) summary
    smart00410
    Location:78173
    IG_like; Immunoglobulin like
    pfam07686
    Location:76190
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:205272
    Ig; Immunoglobulin domain
  2. XM_011512469.1XP_011510771.1  immunoglobulin superfamily member 11 isoform X4

    See identical proteins and their annotated locations for XP_011510771.1

    UniProtKB/Swiss-Prot
    Q5DX21
    Related
    ENSP00000346700.2, ENST00000354673.6
    Conserved Domains (2) summary
    pfam07686
    Location:26140
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:157218
    Ig_3; Immunoglobulin domain
  3. XM_011512463.1XP_011510765.1  immunoglobulin superfamily member 11 isoform X1

    See identical proteins and their annotated locations for XP_011510765.1

    Conserved Domains (3) summary
    smart00410
    Location:78173
    IG_like; Immunoglobulin like
    pfam07686
    Location:76190
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:205272
    Ig; Immunoglobulin domain
  4. XM_011512464.2XP_011510766.1  immunoglobulin superfamily member 11 isoform X1

    See identical proteins and their annotated locations for XP_011510766.1

    Conserved Domains (3) summary
    smart00410
    Location:78173
    IG_like; Immunoglobulin like
    pfam07686
    Location:76190
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:205272
    Ig; Immunoglobulin domain
  5. XM_011512471.3XP_011510773.1  immunoglobulin superfamily member 11 isoform X5

    Conserved Domains (2) summary
    smart00410
    Location:79174
    IG_like; Immunoglobulin like
    pfam07686
    Location:77191
    V-set; Immunoglobulin V-set domain
  6. XM_011512466.2XP_011510768.1  immunoglobulin superfamily member 11 isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:79174
    IG_like; Immunoglobulin like
    pfam07686
    Location:77191
    V-set; Immunoglobulin V-set domain
  7. XM_024453376.1XP_024309144.1  immunoglobulin superfamily member 11 isoform X3

    Conserved Domains (2) summary
    pfam07686
    Location:39153
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:170231
    Ig_3; Immunoglobulin domain
  8. XM_017005789.1XP_016861278.1  immunoglobulin superfamily member 11 isoform X6

    Conserved Domains (2) summary
    pfam13927
    Location:99160
    Ig_3; Immunoglobulin domain
    cl11960
    Location:878
    Ig; Immunoglobulin domain
  9. XM_011512474.3XP_011510776.1  immunoglobulin superfamily member 11 isoform X8

    Conserved Domains (3) summary
    smart00410
    Location:79174
    IG_like; Immunoglobulin like
    pfam07686
    Location:77191
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:206273
    Ig; Immunoglobulin domain
  10. XM_024453377.1XP_024309145.1  immunoglobulin superfamily member 11 isoform X7

    Conserved Domains (2) summary
    pfam07686
    Location:77191
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:208269
    Ig_3; Immunoglobulin domain
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