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Mst1 macrophage stimulating 1 (hepatocyte growth factor-like) [ Mus musculus (house mouse) ]

Gene ID: 15235, updated on 9-Apr-2019

Summary

Official Symbol
Mst1provided by MGI
Official Full Name
macrophage stimulating 1 (hepatocyte growth factor-like)provided by MGI
Primary source
MGI:MGI:96080
See related
Ensembl:ENSMUSG00000032591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hgfl; D3F15S2h; DNF15S2h; D9H3F15S2
Expression
Biased expression in liver adult (RPKM 91.5), liver E18 (RPKM 53.6) and 2 other tissues See more
Orthologs

Genomic context

See Mst1 in Genome Data Viewer
Location:
9 F1; 9 59.07 cM
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (108080405..108085027)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107982767..107987358)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene microRNA 7088 Neighboring gene acylpeptide hydrolase Neighboring gene predicted gene, 46132 Neighboring gene bassoon

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
embryo implantation IDA
Inferred from Direct Assay
more info
PubMed 
mammary duct terminal end bud growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mammary gland epithelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of JAK-STAT cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
vacuole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hepatocyte growth factor-like protein
Names
MSP
macrophage stimulatory protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008243.3NP_032269.3  hepatocyte growth factor-like protein precursor

    See identical proteins and their annotated locations for NP_032269.3

    Status: VALIDATED

    Source sequence(s)
    AC137678, AK134222, M74181
    Consensus CDS
    CCDS40766.1
    UniProtKB/Swiss-Prot
    P26928
    UniProtKB/TrEMBL
    Q3UZ05
    Related
    ENSMUSP00000035211.7, ENSMUST00000035211.13
    Conserved Domains (4) summary
    smart00020
    Location:488709
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:377459
    KR; Kringle domain
    cd00190
    Location:489712
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00024
    Location:2596
    PAN_1; PAN domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    108080405..108085027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511639.3XP_006511702.2  hepatocyte growth factor-like protein isoform X1

    Conserved Domains (2) summary
    smart00130
    Location:400482
    KR; Kringle domain
    pfam00024
    Location:2596
    PAN_1; PAN domain
  2. XM_011242856.2XP_011241158.1  hepatocyte growth factor-like protein isoform X2

    Conserved Domains (2) summary
    smart00020
    Location:230451
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:231454
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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