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Mst1 macrophage stimulating 1 (hepatocyte growth factor-like) [ Mus musculus (house mouse) ]

Gene ID: 15235, updated on 26-Feb-2023

Summary

Official Symbol
Mst1provided by MGI
Official Full Name
macrophage stimulating 1 (hepatocyte growth factor-like)provided by MGI
Primary source
MGI:MGI:96080
See related
Ensembl:ENSMUSG00000032591 AllianceGenome:MGI:96080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hgfl; D3F15S2h; DNF15S2h; D9H3F15S2
Summary
Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including embryo implantation; mammary duct terminal end bud growth; and positive regulation of mammary gland epithelial cell proliferation. Located in vacuole. Is expressed in esophagus epithelium; liver; liver parenchyma; pharynx epithelium; and stomach proventricular region epithelium. Orthologous to several human genes including MST1 (macrophage stimulating 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 91.5), liver E18 (RPKM 53.6) and 2 other tissues See more
Orthologs
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Genomic context

See Mst1 in Genome Data Viewer
Location:
9 F1; 9 59.07 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107957607..107962226)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108080409..108085027)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene microRNA 7088 Neighboring gene acylpeptide hydrolase Neighboring gene bassoon Neighboring gene RIKEN cDNA 4930447F24 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in vacuole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hepatocyte growth factor-like protein
Names
MSP
macrophage stimulatory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008243.3NP_032269.3  hepatocyte growth factor-like protein precursor

    See identical proteins and their annotated locations for NP_032269.3

    Status: VALIDATED

    Source sequence(s)
    AC137678, AK134222, M74181
    Consensus CDS
    CCDS40766.1
    UniProtKB/Swiss-Prot
    P26928, Q6GTL1
    UniProtKB/TrEMBL
    Q3UZ05
    Related
    ENSMUSP00000035211.8, ENSMUST00000035211.14
    Conserved Domains (4) summary
    smart00020
    Location:488709
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:377459
    KR; Kringle domain
    cd00190
    Location:489712
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00024
    Location:2596
    PAN_1; PAN domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107957607..107962226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511639.5XP_006511702.2  hepatocyte growth factor-like protein isoform X1

    Conserved Domains (3) summary
    smart00130
    Location:400482
    KR; Kringle domain
    pfam00051
    Location:191268
    Kringle; Kringle domain
    pfam00024
    Location:2596
    PAN_1; PAN domain
  2. XM_011242856.4XP_011241158.1  hepatocyte growth factor-like protein isoform X2

    Conserved Domains (1) summary
    cd00190
    Location:231454
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_030244059.1XP_030099919.1  hepatocyte growth factor-like protein isoform X3

    Conserved Domains (3) summary
    smart00130
    Location:46128
    KR; Kringle domain
    cd00190
    Location:158381
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl00100
    Location:439
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
  4. XM_030244060.1XP_030099920.1  hepatocyte growth factor-like protein isoform X4

    Conserved Domains (1) summary
    cd00190
    Location:143366
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...