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Foxd1 forkhead box D1 [ Mus musculus (house mouse) ]

Gene ID: 15229, updated on 18-Sep-2024

Summary

Official Symbol
Foxd1provided by MGI
Official Full Name
forkhead box D1provided by MGI
Primary source
MGI:MGI:1347463
See related
Ensembl:ENSMUSG00000078302 AllianceGenome:MGI:1347463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BF-2; Hfh10; FREAC4; Hfhbf2
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including kidney development; luteinizing hormone secretion; and regulation of gene expression. Acts upstream of or within axon guidance; branching involved in ureteric bud morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Orthologous to human FOXD1 (forkhead box D1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Foxd1 in Genome Data Viewer
Location:
13 D1; 13 51.96 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98490753..98493213)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98354245..98356705)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35418 Neighboring gene basic transcription factor 3 Neighboring gene predicted gene 9828 Neighboring gene STARR-seq mESC enhancer starr_35419 Neighboring gene STARR-seq mESC enhancer starr_35420 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_35422 Neighboring gene RIKEN cDNA 2310005E17 gene Neighboring gene predicted gene, 46437 Neighboring gene predicted gene, 52050

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dichotomous subdivision of terminal units involved in ureteric bud branching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in luteinizing hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric capsule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric capsule specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nephrogenic mesenchyme development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pattern specification involved in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
forkhead box protein D1
Names
FORKHEAD BOX PROTEIN D1 (FORKHEAD-RELATED PROTEIN FKHL8) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 4) (FREAC-4)
FREAC-4
HFH-BF-2
HNF-3/forkhead homolog, brain factor 2
brain factor 2
forkhead-related protein FKHL8
forkhead-related transcription factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008242.2NP_032268.2  forkhead box protein D1

    See identical proteins and their annotated locations for NP_032268.2

    Status: VALIDATED

    Source sequence(s)
    AK132390, AK142034
    Consensus CDS
    CCDS36759.1
    UniProtKB/Swiss-Prot
    Q3UQW8, Q61345
    Related
    ENSMUSP00000100725.4, ENSMUST00000105098.6
    Conserved Domains (1) summary
    pfam00250
    Location:130216
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    98490753..98493213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)