Format

Send to:

Choose Destination

FGD5 FYVE, RhoGEF and PH domain containing 5 [ Homo sapiens (human) ]

Gene ID: 152273, updated on 16-Sep-2019

Summary

Official Symbol
FGD5provided by HGNC
Official Full Name
FYVE, RhoGEF and PH domain containing 5provided by HGNC
Primary source
HGNC:HGNC:19117
See related
Ensembl:ENSG00000154783 MIM:614788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFYVE23
Expression
Broad expression in spleen (RPKM 15.9), lung (RPKM 13.8) and 22 other tissues See more
Orthologs

Genomic context

See FGD5 in Genome Data Viewer
Location:
3p25.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (14818962..14934571)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (14852247..14976072)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene meiotic recombination hotspot H Neighboring gene long intergenic non-protein coding RNA 2011 Neighboring gene Sharpr-MPRA regulatory region 8692 Neighboring gene uncharacterized LOC105376963 Neighboring gene FGD5 antisense RNA 1 Neighboring gene nuclear receptor subfamily 2 group C member 2 Neighboring gene mitochondrial ribosomal protein S25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
FYVE, RhoGEF and PH domain-containing protein 5
Names
zinc finger FYVE domain-containing protein 23

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320276.1NP_001307205.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC090937, AW589887, BC144300, DB293373
    UniProtKB/TrEMBL
    B7ZM68
    Related
    ENSP00000445949.1, ENST00000543601.5
    Conserved Domains (5) summary
    cd15792
    Location:11011223
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:12371303
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
    pfam00169
    Location:11161207
    PH; PH domain
    pfam00621
    Location:8961083
    RhoGEF; RhoGEF domain
    cl17171
    Location:13561413
    PH-like; Pleckstrin homology-like domain
  2. NM_152536.4NP_689749.3  FYVE, RhoGEF and PH domain-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_689749.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087591, AC090937
    Consensus CDS
    CCDS46767.1
    UniProtKB/Swiss-Prot
    Q6ZNL6
    Related
    ENSP00000285046.5, ENST00000285046.9
    Conserved Domains (5) summary
    PHA03169
    Location:132323
    PHA03169; hypothetical protein; Provisional
    cd13237
    Location:13661456
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15792
    Location:11011223
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:12371303
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
    pfam00621
    Location:8961082
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    14818962..14934571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533422.1XP_011531724.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X1

    Conserved Domains (5) summary
    cd13237
    Location:13681458
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15792
    Location:11011223
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:12371303
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
    pfam00169
    Location:11161207
    PH; PH domain
    pfam00621
    Location:8961083
    RhoGEF; RhoGEF domain
  2. XM_011533423.1XP_011531725.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

    Conserved Domains (5) summary
    cd15792
    Location:11011223
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:12371303
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
    pfam00169
    Location:11161207
    PH; PH domain
    pfam00621
    Location:8961083
    RhoGEF; RhoGEF domain
    cl17171
    Location:13581415
    PH-like; Pleckstrin homology-like domain
Support Center