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PYDC2 pyrin domain containing 2 [ Homo sapiens (human) ]

Gene ID: 152138, updated on 22-May-2022

Summary

Official Symbol
PYDC2provided by HGNC
Official Full Name
pyrin domain containing 2provided by HGNC
Primary source
HGNC:HGNC:33512
See related
Ensembl:ENSG00000253548 MIM:615701; AllianceGenome:HGNC:33512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POP2; cPOP2
Summary
Involved in several processes, including negative regulation of NLRP3 inflammasome complex assembly; negative regulation of signal transduction; and regulation of gene expression. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See PYDC2 in Genome Data Viewer
Location:
3q28
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (191461163..191461456)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (194270290..194270583)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (191178952..191179245)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene urotensin 2B Neighboring gene coiled-coil domain containing 50 Neighboring gene Sharpr-MPRA regulatory region 6572 Neighboring gene PYDC2 antisense RNA 1 Neighboring gene uncharacterized LOC124909472 Neighboring gene uncharacterized LOC105374275

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pyrin domain-containing protein 2
Names
cellular POP2
pyrin-only protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083308.1NP_001076777.1  pyrin domain-containing protein 2

    See identical proteins and their annotated locations for NP_001076777.1

    Status: VALIDATED

    Source sequence(s)
    AY858112
    UniProtKB/Swiss-Prot
    Q56P42
    Related
    ENSP00000492367.1, ENST00000518817.1
    Conserved Domains (1) summary
    cd08320
    Location:1194
    Pyrin_NALPs; Pyrin death domain found in NALP proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    191461163..191461456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    194270290..194270583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)