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NEK10 NIMA related kinase 10 [ Homo sapiens (human) ]

Gene ID: 152110, updated on 4-Nov-2022

Summary

Official Symbol
NEK10provided by HGNC
Official Full Name
NIMA related kinase 10provided by HGNC
Primary source
HGNC:HGNC:18592
See related
Ensembl:ENSG00000163491 MIM:618726; AllianceGenome:HGNC:18592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CILD44
Summary
Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 2.8), brain (RPKM 0.3) and 6 other tissues See more
Orthologs
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Genomic context

See NEK10 in Genome Data Viewer
Location:
3p24.1
Exon count:
47
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (27106484..27369383, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (27108644..27371532, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (27147975..27410874, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene LRRC3B antisense RNA 1 Neighboring gene uncharacterized LOC124909488 Neighboring gene leucine rich repeat containing 3B Neighboring gene MICOS10 pseudogene 3 Neighboring gene RNA, U6 small nuclear 342, pseudogene Neighboring gene solute carrier family 4 member 7 Neighboring gene ribosomal protein S20 pseudogene 15 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Ciliary dyskinesia, primary, 44
MedGen: C5394063 OMIM: 618781 GeneReviews: Not available
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EBI GWAS Catalog

Description
A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32685

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
part_of protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase Nek10
Names
NIMA (never in mitosis gene a)- related kinase 10
never in mitosis A-related kinase 10
nimA-related protein kinase 10
NP_001026911.1
NP_001291313.1
NP_001381892.1
NP_001381893.1
NP_001381894.1
NP_001381895.1
NP_001381896.1
NP_001381897.1
NP_001381898.1
NP_001381899.1
NP_001381900.1
NP_689747.3
NP_955379.2
XP_006713061.1
XP_006713062.1
XP_006713064.1
XP_011531716.1
XP_016861251.1
XP_016861252.1
XP_016861253.1
XP_016861254.1
XP_016861257.1
XP_016861263.1
XP_047303461.1
XP_047303462.1
XP_047303463.1
XP_047303464.1
XP_047303465.1
XP_047303466.1
XP_047303467.1
XP_047303468.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031741.5NP_001026911.1  serine/threonine-protein kinase Nek10 isoform 1

    See identical proteins and their annotated locations for NP_001026911.1

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931
    UniProtKB/Swiss-Prot
    Q6ZWH5
    UniProtKB/TrEMBL
    Q8N774
    Related
    ENSP00000373281.4, ENST00000383771.8
    Conserved Domains (1) summary
    cl21453
    Location:1097
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001304384.3NP_001291313.1  serine/threonine-protein kinase Nek10 isoform 4

    See identical proteins and their annotated locations for NP_001291313.1

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931
    Consensus CDS
    CCDS77713.1
    UniProtKB/Swiss-Prot
    Q6ZWH5
    Related
    ENSP00000295720.6, ENST00000295720.10
    Conserved Domains (1) summary
    cl21453
    Location:1097
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001394963.1NP_001381892.1  serine/threonine-protein kinase Nek10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  4. NM_001394964.1NP_001381893.1  serine/threonine-protein kinase Nek10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    Conserved Domains (1) summary
    cd08528
    Location:489756
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  5. NM_001394965.1NP_001381894.1  serine/threonine-protein kinase Nek10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/TrEMBL
    A0A650C2C8
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  6. NM_001394966.1NP_001381895.1  serine/threonine-protein kinase Nek10 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    Consensus CDS
    CCDS93229.1
    UniProtKB/TrEMBL
    A0A8I5KTB8
    Related
    ENSP00000509472.1, ENST00000691995.1
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  7. NM_001394967.1NP_001381896.1  serine/threonine-protein kinase Nek10 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    Conserved Domains (1) summary
    cd08528
    Location:489756
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  8. NM_001394968.1NP_001381897.1  serine/threonine-protein kinase Nek10 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    Conserved Domains (1) summary
    cl21453
    Location:525746
    PKc_like; Protein Kinases, catalytic domain
  9. NM_001394969.1NP_001381898.1  serine/threonine-protein kinase Nek10 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    Conserved Domains (1) summary
    cl21453
    Location:489689
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001394970.1NP_001381899.1  serine/threonine-protein kinase Nek10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/Swiss-Prot
    Q96MB3
    Related
    ENSP00000395849.2, ENST00000429845.6
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  11. NM_001394971.1NP_001381900.1  serine/threonine-protein kinase Nek10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/TrEMBL
    A0A650C2C8
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  12. NM_152534.6NP_689747.3  serine/threonine-protein kinase Nek10 isoform 2

    See identical proteins and their annotated locations for NP_689747.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the inferred longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC093555, AC098931, AC099535
    UniProtKB/Swiss-Prot
    Q6ZWH5, Q96MB3
    UniProtKB/TrEMBL
    Q8N774
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  13. NM_199347.4NP_955379.2  serine/threonine-protein kinase Nek10 isoform 3

    See identical proteins and their annotated locations for NP_955379.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, compared to variant 2, resulting in a different 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AK098832, AK123061, BX537852
    Consensus CDS
    CCDS46781.1
    UniProtKB/Swiss-Prot
    Q6ZWH5
    UniProtKB/TrEMBL
    Q8N774
    Related
    ENSP00000343847.5, ENST00000341435.9
    Conserved Domains (2) summary
    smart00220
    Location:519695
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518697
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    27106484..27369383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447506.1XP_047303462.1  serine/threonine-protein kinase Nek10 isoform X6

  2. XM_047447508.1XP_047303464.1  serine/threonine-protein kinase Nek10 isoform X8

  3. XM_017005763.2XP_016861252.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZWH5, Q96MB3
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  4. XM_047447507.1XP_047303463.1  serine/threonine-protein kinase Nek10 isoform X7

  5. XM_017005768.2XP_016861257.1  serine/threonine-protein kinase Nek10 isoform X4

  6. XM_006713001.4XP_006713064.1  serine/threonine-protein kinase Nek10 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KTB8
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  7. XM_047447505.1XP_047303461.1  serine/threonine-protein kinase Nek10 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KTB8
  8. XM_017005762.3XP_016861251.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZWH5, Q96MB3
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  9. XM_017005764.2XP_016861253.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZWH5, Q96MB3
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  10. XM_017005765.2XP_016861254.1  serine/threonine-protein kinase Nek10 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZWH5, Q96MB3
    Conserved Domains (1) summary
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  11. XM_006712999.4XP_006713062.1  serine/threonine-protein kinase Nek10 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  12. XM_006712998.3XP_006713061.1  serine/threonine-protein kinase Nek10 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  13. XM_047447509.1XP_047303465.1  serine/threonine-protein kinase Nek10 isoform X9

  14. XM_011533414.3XP_011531716.1  serine/threonine-protein kinase Nek10 isoform X12

    Conserved Domains (2) summary
    smart00220
    Location:519669
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518672
    PKc_like; Protein Kinases, catalytic domain
  15. XM_047447512.1XP_047303468.1  serine/threonine-protein kinase Nek10 isoform X14

  16. XM_047447511.1XP_047303467.1  serine/threonine-protein kinase Nek10 isoform X13

  17. XM_047447510.1XP_047303466.1  serine/threonine-protein kinase Nek10 isoform X11

  18. XM_017005774.3XP_016861263.1  serine/threonine-protein kinase Nek10 isoform X10

    Conserved Domains (2) summary
    smart00220
    Location:519669
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518672
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001740034.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    27108644..27371532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)