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ZCWPW2 zinc finger CW-type and PWWP domain containing 2 [ Homo sapiens (human) ]

Gene ID: 152098, updated on 13-May-2022

Summary

Official Symbol
ZCWPW2provided by HGNC
Official Full Name
zinc finger CW-type and PWWP domain containing 2provided by HGNC
Primary source
HGNC:HGNC:23574
See related
Ensembl:ENSG00000206559 AllianceGenome:HGNC:23574
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZCW2
Summary
Enables methylated histone binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 1.3), fat (RPKM 0.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZCWPW2 in Genome Data Viewer
Location:
3p24.1
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (28348721..28526358)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (28350777..28528247)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (28390212..28567849)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377008 Neighboring gene C-X9-C motif containing 1 Neighboring gene Sharpr-MPRA regulatory region 24 Neighboring gene 5-azacytidine induced 2 Neighboring gene CIAO2A pseudogene 1 Neighboring gene ribosomal protein L34 pseudogene 11 Neighboring gene protein transport protein SEC31-like Neighboring gene long intergenic non-protein coding RNA 693 Neighboring gene uncharacterized LOC105377009

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger CW-type PWWP domain protein 2
Names
zinc finger CW-type and PWWP domain 2
zinc finger, CW type with PWWP domain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040432.4NP_001035522.1  zinc finger CW-type PWWP domain protein 2 isoform a

    See identical proteins and their annotated locations for NP_001035522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC093142, AC098616, BC094696, BU508346, DB306158, DB451817
    Consensus CDS
    CCDS33723.1
    UniProtKB/Swiss-Prot
    Q504Y3
    Related
    ENSP00000373278.2, ENST00000383768.7
    Conserved Domains (2) summary
    pfam07496
    Location:3077
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:97160
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  2. NM_001324169.2NP_001311098.1  zinc finger CW-type PWWP domain protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC093142, AC098616
    Consensus CDS
    CCDS33723.1
    UniProtKB/Swiss-Prot
    Q504Y3
    Conserved Domains (2) summary
    pfam07496
    Location:3077
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:97160
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  3. NM_001324170.2NP_001311099.1  zinc finger CW-type PWWP domain protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3)
    Source sequence(s)
    AC093142, AC098616

RNA

  1. NR_136708.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4)
    Source sequence(s)
    AC093142, AC098616

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    28348721..28526358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    28350777..28528247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)