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ROPN1B rhophilin associated tail protein 1B [ Homo sapiens (human) ]

Gene ID: 152015, updated on 17-Jun-2019

Summary

Official Symbol
ROPN1Bprovided by HGNC
Official Full Name
rhophilin associated tail protein 1Bprovided by HGNC
Primary source
HGNC:HGNC:31927
See related
Ensembl:ENSG00000114547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 113.4) See more
Orthologs

Genomic context

See ROPN1B in Genome Data Viewer
Location:
3q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (125969161..125983454)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (125687987..125702297)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 86, member A pseudogene Neighboring gene ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like Neighboring gene fibrosin like 1 pseudogene Neighboring gene solute carrier family 41 member 3 Neighboring gene uncharacterized LOC105374085 Neighboring gene uncharacterized LOC112267887

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity NAS
Non-traceable Author Statement
more info
PubMed 
receptor signaling complex scaffold activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
acrosome reaction NAS
Non-traceable Author Statement
more info
PubMed 
cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cilium organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton-dependent cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
flagellated sperm motility TAS
Traceable Author Statement
more info
PubMed 
fusion of sperm to egg plasma membrane involved in single fertilization NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
protein localization to cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
sperm capacitation ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
motile cilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ropporin-1B
Names
AKAP-binding sperm protein ropporin
rhophilin-associated protein 1B
ropporin, rhophilin associated protein 1B
testis tissue sperm-binding protein Li 83P

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012337.3NP_001012337.1  ropporin-1B

    See identical proteins and their annotated locations for NP_001012337.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF231410, HY006578
    Consensus CDS
    CCDS33841.1
    UniProtKB/Swiss-Prot
    Q9BZX4
    UniProtKB/TrEMBL
    A0A140VKG6
    Related
    ENSP00000251776.4, ENST00000251776.8
    Conserved Domains (1) summary
    cl02594
    Location:1244
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
  2. NM_001308313.2NP_001295242.1  ropporin-1B

    See identical proteins and their annotated locations for NP_001295242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC141849, DC397187
    Consensus CDS
    CCDS33841.1
    UniProtKB/Swiss-Prot
    Q9BZX4
    UniProtKB/TrEMBL
    A0A140VKG6
    Related
    ENSP00000426271.1, ENST00000514116.6
    Conserved Domains (1) summary
    cl02594
    Location:1244
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    125969161..125983454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713513.3XP_006713576.1  ropporin-1B isoform X1

    See identical proteins and their annotated locations for XP_006713576.1

    UniProtKB/Swiss-Prot
    Q9BZX4
    UniProtKB/TrEMBL
    A0A140VKG6
    Conserved Domains (1) summary
    cl02594
    Location:1244
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
  2. XM_005247138.3XP_005247195.1  ropporin-1B isoform X2

    See identical proteins and their annotated locations for XP_005247195.1

    UniProtKB/Swiss-Prot
    Q9BZX4
    Related
    ENSP00000421662.1, ENST00000505382.5
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