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Hells helicase, lymphoid specific [ Mus musculus (house mouse) ]

Gene ID: 15201, updated on 5-Jan-2023

Summary

Official Symbol
Hellsprovided by MGI
Official Full Name
helicase, lymphoid specificprovided by MGI
Primary source
MGI:MGI:106209
See related
Ensembl:ENSMUSG00000025001 AllianceGenome:MGI:106209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LSH; Lysh; PASG; YFK8; E130115I21Rik
Summary
Enables chromatin binding activity. Involved in DNA methylation-dependent heterochromatin assembly; maintenance of DNA methylation; and pericentric heterochromatin assembly. Acts upstream of or within several processes, including DNA methylation; cellular response to leukemia inhibitory factor; and negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and pericentric heterochromatin. Is expressed in several structures, including central nervous system; gut; neural retina; reproductive system; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 12.2), liver E14 (RPKM 8.5) and 10 other tissues See more
Orthologs
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Genomic context

See Hells in Genome Data Viewer
Location:
19; 19 C3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (38913282..38958914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (38930262..38970470)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene NOC3 like DNA replication regulator Neighboring gene TBC1D12: TBC1 domain family, member 12 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 55

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA methylation-dependent heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymphocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in lymphocyte proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lymphocyte proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression via chromosomal DNA cytosine methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of gene expression via chromosomal DNA cytosine methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pericentric heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pericentric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within urogenital system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lymphocyte-specific helicase
Names
proliferation-associated SNF2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008234.3NP_032260.2  lymphocyte-specific helicase

    See identical proteins and their annotated locations for NP_032260.2

    Status: VALIDATED

    Source sequence(s)
    AF155210
    Consensus CDS
    CCDS29789.1
    UniProtKB/Swiss-Prot
    Q60848, Q9CYV7
    Related
    ENSMUSP00000025965.6, ENSMUST00000025965.12
    Conserved Domains (2) summary
    PLN03142
    Location:204781
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18009
    Location:203436
    DEXHc_HELLS_SMARCA6; DEXH-box helicase domain of HELLS

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    38913282..38958914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526699.5XP_006526762.1  lymphocyte-specific helicase isoform X1

    See identical proteins and their annotated locations for XP_006526762.1

    UniProtKB/Swiss-Prot
    Q60848, Q9CYV7
    Conserved Domains (2) summary
    PLN03142
    Location:204781
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18009
    Location:203436
    DEXHc_HELLS_SMARCA6; DEXH-box helicase domain of HELLS
  2. XM_006526700.4XP_006526763.1  lymphocyte-specific helicase isoform X2

    Conserved Domains (1) summary
    PLN03142
    Location:4437
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional