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GLIPR2 GLI pathogenesis related 2 [ Homo sapiens (human) ]

Gene ID: 152007, updated on 1-Jun-2020

Summary

Official Symbol
GLIPR2provided by HGNC
Official Full Name
GLI pathogenesis related 2provided by HGNC
Primary source
HGNC:HGNC:18007
See related
Ensembl:ENSG00000122694 MIM:607141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAPR1; GAPR-1; C9orf19
Expression
Broad expression in lung (RPKM 23.8), appendix (RPKM 20.8) and 24 other tissues See more
Orthologs

Genomic context

See GLIPR2 in Genome Data Viewer
Location:
9p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (36136536..36163913)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36136730..36163910)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AM member 1 pseudogene Neighboring gene reversion inducing cysteine rich protein with kazal motifs Neighboring gene calicin Neighboring gene clathrin light chain A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Golgi-associated plant pathogenesis-related protein 1
Names
17kD fetal brain protein
gliPR 2
glioma pathogenesis-related protein 2
golgi-associated PR-1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287010.1NP_001273939.1  Golgi-associated plant pathogenesis-related protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AI458414, AK091288, BF515272, BF516600
    Consensus CDS
    CCDS69595.1
    UniProtKB/TrEMBL
    Q5VZR0
    Related
    ENSP00000367195.1, ENST00000377959.5
    Conserved Domains (1) summary
    cd05382
    Location:8113
    SCP_GAPR-1_like; SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian ...
  2. NM_001287011.2NP_001273940.1  Golgi-associated plant pathogenesis-related protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in its 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AI458414, AK091288, AK307243, BF515272
    Conserved Domains (1) summary
    cd05382
    Location:8102
    SCP_GAPR-1_like; SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian ...
  3. NM_001287012.1NP_001273941.1  Golgi-associated plant pathogenesis-related protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AI458414, AK091288, BF515272, BF516600, DA432700
    Consensus CDS
    CCDS75832.1
    UniProtKB/TrEMBL
    A0A088AWP7
    Related
    ENSP00000379857.4, ENST00000396613.7
    Conserved Domains (1) summary
    cl00133
    Location:859
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
  4. NM_001287013.1NP_001273942.1  Golgi-associated plant pathogenesis-related protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AI458414, AK091288, DA268281
    Conserved Domains (1) summary
    cd05382
    Location:23154
    SCP_GAPR-1_like; SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian ...
  5. NM_001287014.1NP_001273943.1  Golgi-associated plant pathogenesis-related protein 1 isoform f

    See identical proteins and their annotated locations for NP_001273943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, and it lacks three internal coding exons, compared to variant 1. The encoded isoform (f) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AI458414, AK091288, DA268281, N41831
    Consensus CDS
    CCDS75833.1
    UniProtKB/TrEMBL
    A0A087WUM5
    Related
    ENSP00000478768.1, ENST00000619700.1
    Conserved Domains (1) summary
    cl00133
    Location:2057
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
  6. NM_022343.4NP_071738.1  Golgi-associated plant pathogenesis-related protein 1 isoform a

    See identical proteins and their annotated locations for NP_071738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AI458414, AK075091, AK091288, BF515272
    Consensus CDS
    CCDS6598.1
    UniProtKB/Swiss-Prot
    Q9H4G4
    Related
    ENSP00000367196.4, ENST00000377960.9
    Conserved Domains (1) summary
    cd05382
    Location:8139
    SCP_GAPR-1_like; SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian ...

RNA

  1. NR_104637.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) includes two additional exons in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI458414, AK091288, BF515272, BF516600, CR749781
  2. NR_104638.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AI458414, AK091288, BF516600, DA271525
  3. NR_104639.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) includes an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI458414, AK091288, BF515272, BF516600, DA986727
  4. NR_104640.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI458414, AK091288, BF515272, BF516600, DA824243
  5. NR_104641.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AI458414, AK091288, BF515272, BF516600, BP261391

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    36136536..36163913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447416.1XP_024303184.1  Golgi-associated plant pathogenesis-related protein 1 isoform X1

    Conserved Domains (1) summary
    cl00133
    Location:2374
    SCP; SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell ...
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