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Hbegf heparin-binding EGF-like growth factor [ Mus musculus (house mouse) ]

Gene ID: 15200, updated on 18-Apr-2024

Summary

Official Symbol
Hbegfprovided by MGI
Official Full Name
heparin-binding EGF-like growth factorprovided by MGI
Primary source
MGI:MGI:96070
See related
Ensembl:ENSMUSG00000024486 AllianceGenome:MGI:96070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dtr; Dts; Hegfl
Summary
Enables epidermal growth factor receptor binding activity; growth factor activity; and heparin binding activity. Involved in positive regulation of keratinocyte migration; positive regulation of smooth muscle cell proliferation; and wound healing, spreading of epidermal cells. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch; heart; oral region gland; telencephalon; and tooth. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 13.0), large intestine adult (RPKM 6.6) and 23 other tissues See more
Orthologs
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Genomic context

Location:
18 B2; 18 19.46 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36637980..36648858, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36504927..36515805, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene cysteine-rich transmembrane module containing 1 Neighboring gene STARR-seq mESC enhancer starr_44284 Neighboring gene prefoldin 1 Neighboring gene STARR-seq mESC enhancer starr_44287 Neighboring gene STARR-seq mESC enhancer starr_44288 Neighboring gene STARR-seq mESC enhancer starr_44290 Neighboring gene predicted gene, 41698 Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 9 Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_44296 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (8)  1 citation

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC107656

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in ERBB2-EGFR signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ERBB2-ERBB4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in blastocyst growth TAS
Traceable Author Statement
more info
PubMed 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of elastin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of keratinocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proheparin-binding EGF-like growth factor
Names
diphtheria toxin receptor
heparin binding epidermal growth factor-like growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010415.2NP_034545.1  proheparin-binding EGF-like growth factor precursor

    See identical proteins and their annotated locations for NP_034545.1

    Status: VALIDATED

    Source sequence(s)
    AK145548, AK164309, AW489543
    Consensus CDS
    CCDS29153.1
    UniProtKB/Swiss-Prot
    Q06186
    UniProtKB/TrEMBL
    Q5FW64
    Related
    ENSMUSP00000025363.6, ENSMUST00000025363.7
    Conserved Domains (1) summary
    PHA02887
    Location:108148
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36637980..36648858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)