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ADRA2C adrenoceptor alpha 2C [ Homo sapiens (human) ]

Gene ID: 152, updated on 11-Jun-2021

Summary

Official Symbol
ADRA2Cprovided by HGNC
Official Full Name
adrenoceptor alpha 2Cprovided by HGNC
Primary source
HGNC:HGNC:283
See related
Ensembl:ENSG00000184160 MIM:104250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR
Summary
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See ADRA2C in Genome Data Viewer
Location:
4p16.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (3766385..3768526)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3768112..3770253)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2171 Neighboring gene long intergenic non-protein coding RNA 2600 Neighboring gene olfactory receptor family 7 subfamily E member 163 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 162 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha-2A adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables alpha2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables epinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of epinephrine secretion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of norepinephrine secretion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of norepinephrine secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of uterine smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor transactivation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of insulin secretion TAS
Traceable Author Statement
more info
 
involved_in regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon terminus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome TAS
Traceable Author Statement
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alpha-2C adrenergic receptor
Names
adrenergic, alpha-2C-, receptor
alpha-2 adrenergic receptor subtype C4
alpha-2C adrenoceptor
alpha-2C adrenoreceptor
alpha-2CAR
alpha2-AR-C4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012640.1 RefSeqGene

    Range
    4817..6958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000683.4NP_000674.2  alpha-2C adrenergic receptor

    See identical proteins and their annotated locations for NP_000674.2

    Status: REVIEWED

    Source sequence(s)
    AC141928
    Consensus CDS
    CCDS47004.1
    UniProtKB/Swiss-Prot
    P18825
    UniProtKB/TrEMBL
    Q4W594
    Related
    ENSP00000386069.2, ENST00000330055.7
    Conserved Domains (1) summary
    cd15323
    Location:60448
    7tmA_alpha2C_AR; alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    3766385..3768526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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