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ADRA2C adrenoceptor alpha 2C [ Homo sapiens (human) ]

Gene ID: 152, updated on 22-Sep-2022

Summary

Official Symbol
ADRA2Cprovided by HGNC
Official Full Name
adrenoceptor alpha 2Cprovided by HGNC
Primary source
HGNC:HGNC:283
See related
Ensembl:ENSG00000184160 MIM:104250; AllianceGenome:HGNC:283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR
Summary
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See ADRA2C in Genome Data Viewer
Location:
4p16.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (3766385..3768526)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (3765283..3767445)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3768112..3770253)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374357 Neighboring gene Sharpr-MPRA regulatory region 9480 Neighboring gene long intergenic non-protein coding RNA 2171 Neighboring gene uncharacterized LOC124900651 Neighboring gene olfactory receptor family 7 subfamily E member 163 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha-2A adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables alpha2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables epinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alpha-2C adrenergic receptor
Names
adrenergic, alpha-2C-, receptor
alpha-2 adrenergic receptor subtype C4
alpha-2C adrenoceptor
alpha-2C adrenoreceptor
alpha-2CAR
alpha2-AR-C4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012640.1 RefSeqGene

    Range
    4817..6958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000683.4NP_000674.2  alpha-2C adrenergic receptor

    See identical proteins and their annotated locations for NP_000674.2

    Status: REVIEWED

    Source sequence(s)
    AC141928
    Consensus CDS
    CCDS47004.1
    UniProtKB/Swiss-Prot
    P18825, Q9HB49
    UniProtKB/TrEMBL
    Q4W594
    Related
    ENSP00000386069.2, ENST00000330055.7
    Conserved Domains (1) summary
    cd15323
    Location:60448
    7tmA_alpha2C_AR; alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    3766385..3768526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    3765283..3767445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)