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ADRA2C adrenoceptor alpha 2C [ Homo sapiens (human) ]

Gene ID: 152, updated on 3-May-2020

Summary

Official Symbol
ADRA2Cprovided by HGNC
Official Full Name
adrenoceptor alpha 2Cprovided by HGNC
Primary source
HGNC:HGNC:283
See related
Ensembl:ENSG00000184160 MIM:104250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR
Summary
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See ADRA2C in Genome Data Viewer
Location:
4p16.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (3766385..3768526)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3768296..3770253)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2171 Neighboring gene long intergenic non-protein coding RNA 2600 Neighboring gene olfactory receptor family 7 subfamily E member 163 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 162 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-2A adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
alpha2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epinephrine secretion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of norepinephrine secretion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of norepinephrine secretion TAS
Traceable Author Statement
more info
PubMed 
negative regulation of uterine smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
receptor transactivation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin secretion TAS
Traceable Author Statement
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon terminus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endosome TAS
Traceable Author Statement
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alpha-2C adrenergic receptor
Names
adrenergic, alpha-2C-, receptor
alpha-2 adrenergic receptor subtype C4
alpha-2C adrenoceptor
alpha-2C adrenoreceptor
alpha-2CAR
alpha2-AR-C4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012640.1 RefSeqGene

    Range
    4817..6958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000683.4NP_000674.2  alpha-2C adrenergic receptor

    See identical proteins and their annotated locations for NP_000674.2

    Status: REVIEWED

    Source sequence(s)
    AC141928
    Consensus CDS
    CCDS47004.1
    UniProtKB/Swiss-Prot
    P18825
    UniProtKB/TrEMBL
    Q4W594
    Related
    ENSP00000386069.2, ENST00000330055.7
    Conserved Domains (2) summary
    pfam00001
    Location:68437
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:60184
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    3766385..3768526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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