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Hdgfl2 HDGF like 2 [ Mus musculus (house mouse) ]

Gene ID: 15193, updated on 9-Mar-2023

Summary

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Official Symbol
Hdgfl2provided by MGI
Official Full Name
HDGF like 2provided by MGI
Primary source
MGI:MGI:1194492
See related
Ensembl:ENSMUSG00000002833 AllianceGenome:MGI:1194492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HRP-2; Hdgfrp2
Summary
Enables chromatin binding activity. Predicted to be involved in positive regulation of cell growth and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in brain; dorsal root ganglion; intestine; and retina. Orthologous to human HDGFL2 (HDGF like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 36.8), testis adult (RPKM 27.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hdgfl2 in Genome Data Viewer
Location:
17; 17 D
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56386601..56407605)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56079599..56100605)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene MPN domain containing Neighboring gene SH3-domain GRB2-like 1 Neighboring gene chromatin assembly factor 1, subunit A (p150) Neighboring gene UBX domain protein 6 Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon CTC) Neighboring gene perilipin 4 Neighboring gene perilipin 5 Neighboring gene leucine-rich alpha-2-glycoprotein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Wang H, et al. Nucleic Acids Res, 2012 Dec. PMID 23042676, Free PMC Article
  2. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. Gao K, et al. Biochem Biophys Res Commun, 2015 Mar 20. PMID 25689719
  3. Interaction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromer. Thakar K, et al. FEBS J, 2012 Mar. PMID 22212508
  4. Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Izumoto Y, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299445
  5. Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival. Van Belle S, et al. Cells, 2021 Jan 19. PMID 33477970, Free PMC Article

See all (35) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.
    Title: Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.
  2. HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.
    Title: HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.
  3. The role of HRP2 protein in cardiac development
    Title: Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.
  4. HRP-2 can promote hepatocellular carcinoma cells growth in vitro and xenograft tumors in vivo.
    Title: HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma.
  5. The results show that HRP2 plays a role in HIV-1 integration when LEDGF/p75 is absent.
    Title: HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables H3K27me3 modified histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables H3K27me3 modified histone binding ISO
Inferred from Sequence Orthology
more info
  
enables H3K9me3 modified histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables H3K9me3 modified histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hepatoma-derived growth factor-related protein 2
Names
hepatoma-derived growth factor, related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304784.2 → NP_001291713.1  hepatoma-derived growth factor-related protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001291713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK146813, BF466128, CT009719
    Consensus CDS
    CCDS89122.1
    UniProtKB/Swiss-Prot
    Q3UMU9
    Related
    ENSMUSP00000153249.2, ENSMUST00000225843.2
    Conserved Domains (2) summary
    cd05834
    Location:3 → 87
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    pfam11467
    Location:477 → 561
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

  2. NM_001304785.2 → NP_001291714.1  hepatoma-derived growth factor-related protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001291714.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate in-frame splice sites in an internal exon and the 3' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AK143616, BF466128, CT009719
    Consensus CDS
    CCDS89123.1
    UniProtKB/Swiss-Prot
    Q3UMU9
    Related
    ENSMUSP00000002911.10, ENSMUST00000002911.10
    Conserved Domains (2) summary
    cd05834
    Location:3 → 87
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    pfam11467
    Location:467 → 551
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

  3. NM_001331053.1 → NP_001317982.1  hepatoma-derived growth factor-related protein 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 4, which is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK146813, BF466128, BY760501, CT009719
    UniProtKB/Swiss-Prot
    Q3UMU9
    Conserved Domains (2) summary
    cd05834
    Location:3 → 87
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    pfam11467
    Location:477 → 561
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

  4. NM_008233.4 → NP_032259.1  hepatoma-derived growth factor-related protein 2 isoform 2

    See identical proteins and their annotated locations for NP_032259.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK143616, BF466128, CT009719
    Consensus CDS
    CCDS28894.1
    UniProtKB/Swiss-Prot
    Q3UMU9, Q99L92
    Related
    ENSMUSP00000152948.2, ENSMUST00000226053.2
    Conserved Domains (2) summary
    cd05834
    Location:3 → 87
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    pfam11467
    Location:468 → 552
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56386601..56407605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523710.5 → XP_006523773.1  hepatoma-derived growth factor-related protein 2 isoform X1

    Conserved Domains (2) summary
    cd05834
    Location:3 → 87
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    pfam11467
    Location:468 → 553
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

  2. XM_030249512.2 → XP_030105372.1  hepatoma-derived growth factor-related protein 2 isoform X3

    Conserved Domains (1) summary
    pfam11467
    Location:352 → 437
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

  3. XM_030249513.2 → XP_030105373.1  hepatoma-derived growth factor-related protein 2 isoform X5

    Conserved Domains (1) summary
    pfam11467
    Location:343 → 428
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

  4. XM_006523708.4 → XP_006523771.1  hepatoma-derived growth factor-related protein 2 isoform X2

    Conserved Domains (1) summary
    pfam11467
    Location:352 → 437
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

  5. XM_006523709.4 → XP_006523772.1  hepatoma-derived growth factor-related protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006523772.1

    Conserved Domains (1) summary
    pfam11467
    Location:343 → 428
    LEDGF; Lens epithelium-derived growth factor (LEDGF)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UMU9.1 GenPept UniProtKB/Swiss-Prot:Q3UMU9

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