U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hdgf heparin binding growth factor [ Mus musculus (house mouse) ]

Gene ID: 15191, updated on 5-Jan-2023

Summary

Official Symbol
Hdgfprovided by MGI
Official Full Name
heparin binding growth factorprovided by MGI
Primary source
MGI:MGI:1194494
See related
Ensembl:ENSMUSG00000004897 AllianceGenome:MGI:1194494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D3Ertd299e
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cytoskeletal protein binding activity; and growth factor activity. Acts upstream of or within cellular response to interleukin-7 and negative regulation of neuron apoptotic process. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; liver; sensory organ; and telencephalon ventricular layer. Orthologous to human HDGF (heparin binding growth factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 92.7), CNS E11.5 (RPKM 90.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hdgf in Genome Data Viewer
Location:
3 F1; 3 38.78 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87813397..87823439)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87906090..87916132)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 2A Neighboring gene papillary renal cell carcinoma (translocation-associated) Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene ribosomal RNA adenine dimethylase domain containing 1 Neighboring gene interferon stimulated exonuclease gene 20-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hepatoma-derived growth factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331051.2NP_001317980.1  hepatoma-derived growth factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158233
  2. NM_001331052.2NP_001317981.1  hepatoma-derived growth factor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158233
    Related
    ENSMUSP00000124803.2, ENSMUST00000159492.8
    Conserved Domains (1) summary
    cl02554
    Location:760
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  3. NM_001410032.1NP_001396961.1  hepatoma-derived growth factor isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158233
  4. NM_001410033.1NP_001396962.1  hepatoma-derived growth factor isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158233
  5. NM_001410034.1NP_001396963.1  hepatoma-derived growth factor isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158233
  6. NM_001410035.1NP_001396964.1  hepatoma-derived growth factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158233
  7. NM_001410036.1NP_001396965.1  hepatoma-derived growth factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158233
  8. NM_001410037.1NP_001396966.1  hepatoma-derived growth factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158233
  9. NM_001410038.1NP_001396967.1  hepatoma-derived growth factor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158233
  10. NM_001410039.1NP_001396968.1  hepatoma-derived growth factor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158233
  11. NM_001410040.1NP_001396969.1  hepatoma-derived growth factor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158233
  12. NM_001410041.1NP_001396970.1  hepatoma-derived growth factor isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC158233
  13. NM_001410042.1NP_001396971.1  hepatoma-derived growth factor isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC158233
  14. NM_008231.5NP_032257.3  hepatoma-derived growth factor isoform 1

    See identical proteins and their annotated locations for NP_032257.3

    Status: VALIDATED

    Source sequence(s)
    AC158233
    Consensus CDS
    CCDS17457.1
    UniProtKB/Swiss-Prot
    P51859, Q9JK87
    Related
    ENSMUSP00000005017.9, ENSMUST00000005017.15
    Conserved Domains (1) summary
    cd05834
    Location:892
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87813397..87823439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252435.1XP_030108295.1  hepatoma-derived growth factor isoform X1

  2. XM_006501029.4XP_006501092.1  hepatoma-derived growth factor isoform X2

    Conserved Domains (1) summary
    cl02554
    Location:760
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  3. XM_030252436.2XP_030108296.1  hepatoma-derived growth factor isoform X1