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DPPA2 developmental pluripotency associated 2 [ Homo sapiens (human) ]

Gene ID: 151871, updated on 21-Dec-2019

Summary

Official Symbol
DPPA2provided by HGNC
Official Full Name
developmental pluripotency associated 2provided by HGNC
Primary source
HGNC:HGNC:19197
See related
Ensembl:ENSG00000163530 MIM:614445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT100; PESCRG1; ECAT15-2
Expression
Restricted expression toward testis (RPKM 2.2) See more
Orthologs

Genomic context

See DPPA2 in Genome Data Viewer
Location:
3q13.13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (109293788..109316589, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (109012635..109035364, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1236, pseudogene Neighboring gene bromodomain containing 7 pseudogene Neighboring gene developmental pluripotency associated 4 Neighboring gene chromosome 12 open reading frame 29 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
developmental pluripotency-associated protein 2
Names
cancer/testis antigen 100
embryonic stem cell (ESC) associated transcript 15-2
pluripotent embryonic stem cell-related gene 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138815.4NP_620170.3  developmental pluripotency-associated protein 2

    See identical proteins and their annotated locations for NP_620170.3

    Status: VALIDATED

    Source sequence(s)
    AA460929, AY283672, BC018070
    Consensus CDS
    CCDS2956.1
    UniProtKB/Swiss-Prot
    Q7Z7J5
    Related
    ENSP00000417710.1, ENST00000478945.1
    Conserved Domains (3) summary
    smart00513
    Location:99122
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14047
    Location:220286
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:133215
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    109293788..109316589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512444.3XP_011510746.1  developmental pluripotency-associated protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011510746.1

    UniProtKB/Swiss-Prot
    Q7Z7J5
    Conserved Domains (3) summary
    smart00513
    Location:99122
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14047
    Location:220286
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:133215
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates
  2. XM_011512445.2XP_011510747.1  developmental pluripotency-associated protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011510747.1

    UniProtKB/Swiss-Prot
    Q7Z7J5
    Conserved Domains (3) summary
    smart00513
    Location:99122
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14047
    Location:220286
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:133215
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates
  3. XM_011512443.1XP_011510745.1  developmental pluripotency-associated protein 2 isoform X1

    Conserved Domains (3) summary
    smart00513
    Location:108131
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14047
    Location:229295
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:142224
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates
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