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DPPA2 developmental pluripotency associated 2 [ Homo sapiens (human) ]

Gene ID: 151871, updated on 9-Jun-2025
Official Symbol
DPPA2provided by HGNC
Official Full Name
developmental pluripotency associated 2provided by HGNC
Primary source
HGNC:HGNC:19197
See related
Ensembl:ENSG00000163530 MIM:614445; AllianceGenome:HGNC:19197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT100; PESCRG1; ECAT15-2
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in system development. Predicted to act upstream of or within several processes, including epigenetic regulation of gene expression; lung-associated mesenchyme development; and positive regulation of stem cell proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Restricted expression toward testis (RPKM 2.2) See more
Orthologs
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See DPPA2 in Genome Data Viewer
Location:
3q13.13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (109293788..109316517, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (112014076..112036840, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (109012635..109035364, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1236, pseudogene Neighboring gene BRD7 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:109043097-109043597 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:109054673-109055281 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:109055282-109055890 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:109055891-109056498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:109057717-109058324 Neighboring gene developmental pluripotency associated 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:109066679-109067180 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:109074429-109075164 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:109075165-109075898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:109075899-109076634 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:109085761-109085928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:109114646-109115452 Neighboring gene RLIG1 pseudogene 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in system development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
developmental pluripotency-associated protein 2
Names
cancer/testis antigen 100
embryonic stem cell (ESC) associated transcript 15-2
pluripotent embryonic stem cell-related gene 1 protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138815.4NP_620170.3  developmental pluripotency-associated protein 2

    See identical proteins and their annotated locations for NP_620170.3

    Status: VALIDATED

    Source sequence(s)
    AA460929, AY283672, BC018070
    Consensus CDS
    CCDS2956.1
    UniProtKB/Swiss-Prot
    Q7Z7J5, Q8WVF0
    Related
    ENSP00000417710.1, ENST00000478945.1
    Conserved Domains (3) summary
    smart00513
    Location:99122
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14047
    Location:220286
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:133215
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    109293788..109316517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512444.4XP_011510746.1  developmental pluripotency-associated protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011510746.1

    UniProtKB/Swiss-Prot
    Q7Z7J5, Q8WVF0
    Conserved Domains (3) summary
    smart00513
    Location:99122
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14047
    Location:220286
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:133215
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates
  2. XM_011512445.3XP_011510747.1  developmental pluripotency-associated protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011510747.1

    UniProtKB/Swiss-Prot
    Q7Z7J5, Q8WVF0
    Conserved Domains (3) summary
    smart00513
    Location:99122
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14047
    Location:220286
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:133215
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates
  3. XM_011512443.2XP_011510745.1  developmental pluripotency-associated protein 2 isoform X1

    Conserved Domains (3) summary
    smart00513
    Location:108131
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14047
    Location:229295
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:142224
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    112014076..112036840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345349.1XP_054201324.1  developmental pluripotency-associated protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q7Z7J5, Q8WVF0
  2. XM_054345350.1XP_054201325.1  developmental pluripotency-associated protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q7Z7J5, Q8WVF0
  3. XM_054345348.1XP_054201323.1  developmental pluripotency-associated protein 2 isoform X1