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Hdc histidine decarboxylase [ Mus musculus (house mouse) ]

Gene ID: 15186, updated on 19-Jun-2024

Summary

Official Symbol
Hdcprovided by MGI
Official Full Name
histidine decarboxylaseprovided by MGI
Primary source
MGI:MGI:96062
See related
Ensembl:ENSMUSG00000027360 AllianceGenome:MGI:96062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hdc-a; Hdc-c; Hdc-e; Hdc-s
Summary
Enables histidine decarboxylase activity. Acts upstream of or within histamine biosynthetic process and histidine catabolic process. Predicted to be located in cytosol; dendrite; and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study Gilles de la Tourette syndrome. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 49.0), lung adult (RPKM 24.4) and 10 other tissues See more
Orthologs
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Genomic context

See Hdc in Genome Data Viewer
Location:
2 F1; 2 61.76 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126435579..126465942, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126593659..126624025, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05604 Neighboring gene STARR-seq mESC enhancer starr_05605 Neighboring gene predicted gene, 26697 Neighboring gene STARR-seq mESC enhancer starr_05606 Neighboring gene solute carrier family 27 (fatty acid transporter), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E11157 Neighboring gene GA repeat binding protein, beta 1 Neighboring gene zinc finger, BED domain containing 4 pseudogene Neighboring gene RIKEN cDNA A630026N12 gene Neighboring gene STARR-seq mESC enhancer starr_05607

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables histidine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histidine decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histidine decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables histidine decarboxylase activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in L-histidine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within L-histidine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-histidine catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-histidine catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in L-histidine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within catecholamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in histamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within histamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histidine decarboxylase
Names
L-histidine decarboxylase
NP_032256.3
XP_006498847.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008230.6NP_032256.3  histidine decarboxylase

    See identical proteins and their annotated locations for NP_032256.3

    Status: VALIDATED

    Source sequence(s)
    AK133455, AV249910, BQ176022
    Consensus CDS
    CCDS16684.1
    UniProtKB/Swiss-Prot
    P23738, Q9QWU3
    UniProtKB/TrEMBL
    Q7TMW5
    Related
    ENSMUSP00000028838.5, ENSMUST00000028838.5
    Conserved Domains (1) summary
    pfam00282
    Location:43421
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126435579..126465942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498784.4XP_006498847.1  histidine decarboxylase isoform X1

    UniProtKB/TrEMBL
    Q7TMW5
    Conserved Domains (1) summary
    pfam00282
    Location:62440
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain