U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hcn2 hyperpolarization-activated, cyclic nucleotide-gated K+ 2 [ Mus musculus (house mouse) ]

Gene ID: 15166, updated on 10-Oct-2024

Summary

Official Symbol
Hcn2provided by MGI
Official Full Name
hyperpolarization-activated, cyclic nucleotide-gated K+ 2provided by MGI
Primary source
MGI:MGI:1298210
See related
Ensembl:ENSMUSG00000020331 AllianceGenome:MGI:1298210
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HAC1; trls; BCNG2
Summary
Predicted to enable several functions, including PDZ domain binding activity; cation channel activity; and identical protein binding activity. Acts upstream of or within regulation of membrane potential. Predicted to be located in several cellular components, including axon; dendrite; and neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to be part of HCN channel complex. Is expressed in heart; heart ventricle; spinal cord; and ventral grey horn. Human ortholog(s) of this gene implicated in familial febrile seizures 2. Orthologous to human HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 65.1), frontal lobe adult (RPKM 31.4) and 10 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hcn2 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79552468..79571942)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79716634..79736108)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10624 Neighboring gene predicted gene, 25794 Neighboring gene basigin Neighboring gene polymerase (RNA) mitochondrial (DNA directed) Neighboring gene STARR-positive B cell enhancer ABC_E3897 Neighboring gene fibroblast growth factor 22

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (4) 
  • Endonuclease-mediated (4) 
  • Spontaneous (3)  1 citation
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly cAMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly cAMP-activated cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ammonium transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to cGMP IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cGMP ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of HCN channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of HCN channel complex IEA
Inferred from Electronic Annotation
more info
 
part_of HCN channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Names
BCNG-2
HAC-1
brain cyclic nucleotide-gated channel 2
hyperpolarization-activated cation channel 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008226.2NP_032252.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

    See identical proteins and their annotated locations for NP_032252.1

    Status: PROVISIONAL

    Source sequence(s)
    AC151828, AF064873, CX242892
    Consensus CDS
    CCDS23986.1
    UniProtKB/Swiss-Prot
    O70506, O88703
    UniProtKB/TrEMBL
    C9K0Z8
    Related
    ENSMUSP00000097113.2, ENSMUST00000099513.8
    Conserved Domains (4) summary
    COG0664
    Location:511646
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:517625
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:202447
    Ion_trans; Ion transport protein
    pfam08412
    Location:140182
    Ion_trans_N; Ion transport protein N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79552468..79571942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)