U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 [ Mus musculus (house mouse) ]

Gene ID: 15165, updated on 18-Sep-2024

Summary

Official Symbol
Hcn1provided by MGI
Official Full Name
hyperpolarization activated cyclic nucleotide gated potassium channel 1provided by MGI
Primary source
MGI:MGI:1096392
See related
Ensembl:ENSMUSG00000021730 AllianceGenome:MGI:1096392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HAC2; Bcng1; C630013B14Rik
Summary
Enables cAMP binding activity; cation channel activity; and identical protein binding activity. Involved in cellular response to cAMP and potassium ion transmembrane transport. Acts upstream of or within apical protein localization and retinal cone cell development. Located in axon and dendrite. Is integral component of plasma membrane. Is expressed in brain; heart; and heart ventricle. Used to study sick sinus syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Orthologous to human HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 5.8), bladder adult (RPKM 5.1) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hcn1 in Genome Data Viewer
Location:
13 D2.3; 13 66.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (117738856..118117564)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (117602320..117981028)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H3 histone, family 3A pseudogene Neighboring gene keratin 18 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35779 Neighboring gene RIKEN cDNA 4933413L06 gene Neighboring gene mitochondrial translational initiation factor 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35780 Neighboring gene predicted gene 3474 Neighboring gene STARR-seq mESC enhancer starr_35782 Neighboring gene predicted gene, 26349 Neighboring gene ribosomal protein S8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential EXP
Inferred from Experiment
more info
PubMed 
enables intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables intracellularly cAMP-activated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables intracellularly cAMP-activated cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated monoatomic cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apical protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cAMP IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within general adaptation syndrome, behavioral process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuronal action potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane potential EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retinal cone cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of HCN channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of HCN channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of HCN channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Names
BCNG-1
HAC-2
brain cyclic nucleotide-gated channel 1
hyperpolarization-activated cation channel 2
hyperpolarization-activated, cyclic nucleotide-gated K+ 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010408.3NP_034538.2  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

    See identical proteins and their annotated locations for NP_034538.2

    Status: VALIDATED

    Source sequence(s)
    AC113036, AF028737, AK014722, AK158322
    Consensus CDS
    CCDS26793.1
    UniProtKB/Swiss-Prot
    O54899, O88704, Q9D613
    Related
    ENSMUSP00000006991.8, ENSMUST00000006991.9
    Conserved Domains (4) summary
    COG0664
    Location:458593
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:464572
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:149394
    Ion_trans; Ion transport protein
    pfam08412
    Location:87129
    Ion_trans_N; Ion transport protein N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    117738856..118117564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)