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TAFA4 TAFA chemokine like family member 4 [ Homo sapiens (human) ]

Gene ID: 151647, updated on 2-Mar-2021

Summary

Official Symbol
TAFA4provided by HGNC
Official Full Name
TAFA chemokine like family member 4provided by HGNC
Primary source
HGNC:HGNC:21591
See related
Ensembl:ENSG00000163377 MIM:617498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAFA-4; FAM19A4
Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Biased expression in adrenal (RPKM 8.7), gall bladder (RPKM 0.7) and 1 other tissue See more
Orthologs
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Genomic context

See TAFA4 in Genome Data Viewer
Location:
3p14.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (68731766..68932610, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (68780917..68981698, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 8 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 135 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene TATA element modulatory factor 1 Neighboring gene microRNA 3136

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor ligand activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macrophage chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
superoxide anion generation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
chemokine-like protein TAFA-4
Names
family with sequence similarity 19 (chemokine (C-C motif)-like), member A4
family with sequence similarity 19 member A4, C-C motif chemokine like
protein FAM19A4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005527.3NP_001005527.1  chemokine-like protein TAFA-4 precursor

    See identical proteins and their annotated locations for NP_001005527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC096922, BC031566, DA017279
    Consensus CDS
    CCDS2907.1
    UniProtKB/Swiss-Prot
    Q96LR4
    UniProtKB/TrEMBL
    A0A024R369
    Conserved Domains (1) summary
    pfam12020
    Location:50138
    TAFA; TAFA family
  2. NM_182522.5NP_872328.1  chemokine-like protein TAFA-4 precursor

    See identical proteins and their annotated locations for NP_872328.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC096922, AY325117
    Consensus CDS
    CCDS2907.1
    UniProtKB/Swiss-Prot
    Q96LR4
    UniProtKB/TrEMBL
    A0A024R369
    Related
    ENSP00000295569.7, ENST00000295569.12
    Conserved Domains (1) summary
    pfam12020
    Location:50138
    TAFA; TAFA family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    68731766..68932610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533371.1XP_011531673.1  chemokine-like protein TAFA-4 isoform X1

    See identical proteins and their annotated locations for XP_011531673.1

    Conserved Domains (1) summary
    pfam12020
    Location:50124
    TAFA; TAFA family
  2. XM_011533372.1XP_011531674.1  chemokine-like protein TAFA-4 isoform X1

    See identical proteins and their annotated locations for XP_011531674.1

    Conserved Domains (1) summary
    pfam12020
    Location:50124
    TAFA; TAFA family
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