U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DTX3L deltex E3 ubiquitin ligase 3L [ Homo sapiens (human) ]

Gene ID: 151636, updated on 17-Sep-2024

Summary

Official Symbol
DTX3Lprovided by HGNC
Official Full Name
deltex E3 ubiquitin ligase 3Lprovided by HGNC
Primary source
HGNC:HGNC:30323
See related
Ensembl:ENSG00000163840 MIM:613143; AllianceGenome:HGNC:30323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BBAP; RNF143
Summary
Enables several functions, including STAT family protein binding activity; ubiquitin-like protein ligase binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein localization; and protein ubiquitination. Located in cytosol; lysosome; and nucleoplasm. Part of protein-containing complex. Colocalizes with early endosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in appendix (RPKM 14.2), spleen (RPKM 13.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DTX3L in Genome Data Viewer
Location:
3q21.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (122564338..122575203)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (125283584..125294443)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122283185..122294050)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984000 Neighboring gene uncharacterized LOC105374071 Neighboring gene Sharpr-MPRA regulatory region 13157 Neighboring gene poly(ADP-ribose) polymerase family member 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14643 Neighboring gene poly(ADP-ribose) polymerase family member 15 Neighboring gene poly(ADP-ribose) polymerase family member 14 pseudogene Neighboring gene uncharacterized LOC124909419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20380 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:122353940-122355139 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A mega-analysis of genome-wide association studies for major depressive disorder.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables STAT family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H4K91 ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone ubiquitin ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein ADP-ribosyltransferase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair-dependent chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of chromatin binding IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of defense response to virus by host IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to early endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase DTX3L
Names
B-lymphoma- and BAL-associated protein
RING-type E3 ubiquitin transferase DTX3L
deltex 3 like, E3 ubiquitin ligase
deltex 3-like
rhysin-2
rhysin2
NP_612144.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138287.3NP_612144.1  E3 ubiquitin-protein ligase DTX3L

    See identical proteins and their annotated locations for NP_612144.1

    Status: VALIDATED

    Source sequence(s)
    AC092908
    Consensus CDS
    CCDS3015.1
    UniProtKB/Swiss-Prot
    B3KWH6, Q53ZZ3, Q5MJP7, Q8TDB6
    Related
    ENSP00000296161.4, ENST00000296161.9
    Conserved Domains (3) summary
    cd09633
    Location:608738
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd12300
    Location:886
    RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cd16712
    Location:560600
    RING-HC_DTX3L; RING finger, HC subclass, found in protein Deltex-3-like (DTX3L) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    122564338..122575203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    125283584..125294443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)