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TTC14 tetratricopeptide repeat domain 14 [ Homo sapiens (human) ]

Gene ID: 151613, updated on 1-Jun-2020

Summary

Official Symbol
TTC14provided by HGNC
Official Full Name
tetratricopeptide repeat domain 14provided by HGNC
Primary source
HGNC:HGNC:24697
See related
Ensembl:ENSG00000163728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRDL5813; PRO19630
Expression
Ubiquitous expression in lymph node (RPKM 14.0), thyroid (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See TTC14 in Genome Data Viewer
Location:
3q26.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (180602163..180618329)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (180319918..180336120)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2053 Neighboring gene uncharacterized LOC101928856 Neighboring gene RNA, U6 small nuclear 486, pseudogene Neighboring gene coiled-coil domain containing 39 Neighboring gene uncharacterized LOC101928882 Neighboring gene VISTA enhancer hs258 Neighboring gene RNA, 7SL, cytoplasmic 229, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00166, KIAA1980, DKFZp313M1015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetratricopeptide repeat protein 14
Names
TPR repeat protein 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042601.3NP_001036066.1  tetratricopeptide repeat protein 14 isoform b

    See identical proteins and their annotated locations for NP_001036066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains two alternate introns compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI742462, AI811067, AL832052, AL833086, BX474122
    Consensus CDS
    CCDS46963.1
    UniProtKB/Swiss-Prot
    Q96N46
    UniProtKB/TrEMBL
    Q69YS0, Q86TA5, Q8TEM7
    Related
    ENSP00000413743.2, ENST00000412756.6
    Conserved Domains (4) summary
    smart00316
    Location:124207
    S1; Ribosomal protein S1-like RNA-binding domain
    sd00006
    Location:307335
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:341374
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:307372
    TPR_11; TPR repeat
  2. NM_001288582.2NP_001275511.1  tetratricopeptide repeat protein 14 isoform c

    See identical proteins and their annotated locations for NP_001275511.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC068298, AI088990, AY358762, BU684626, BX474122
    Consensus CDS
    CCDS75055.1
    UniProtKB/Swiss-Prot
    Q96N46
    Related
    ENSP00000372027.4, ENST00000382584.8
    Conserved Domains (4) summary
    smart00316
    Location:124207
    S1; Ribosomal protein S1-like RNA-binding domain
    sd00006
    Location:307335
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:341374
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:307372
    TPR_11; TPR repeat
  3. NM_133462.4NP_597719.1  tetratricopeptide repeat protein 14 isoform a

    See identical proteins and their annotated locations for NP_597719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AB075860, AI742462, AI811067, AK055984, BX474122
    Consensus CDS
    CCDS3237.1
    UniProtKB/Swiss-Prot
    Q96N46
    Related
    ENSP00000296015.4, ENST00000296015.9
    Conserved Domains (3) summary
    smart00316
    Location:124207
    S1; Ribosomal protein S1-like RNA-binding domain
    COG0457
    Location:290437
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:307335
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    180602163..180618329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005740.2XP_016861229.1  tetratricopeptide repeat protein 14 isoform X3

  2. XM_017005739.2XP_016861228.1  tetratricopeptide repeat protein 14 isoform X1

  3. XM_024453361.1XP_024309129.1  tetratricopeptide repeat protein 14 isoform X2

    Conserved Domains (3) summary
    sd00006
    Location:5785
    TPR; TPR repeat [structural motif]
    cl26002
    Location:67105
    TPR_11; TPR repeat
    cl27036
    Location:22164
    BCSC_C; Cellulose synthase operon protein C C-terminus (BCSC_C)

RNA

  1. XR_427362.4 RNA Sequence

  2. XR_001740030.2 RNA Sequence

  3. XR_001740029.2 RNA Sequence

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