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Hcfc1 host cell factor C1 [ Mus musculus (house mouse) ]

Gene ID: 15161, updated on 8-Dec-2022

Summary

Official Symbol
Hcfc1provided by MGI
Official Full Name
host cell factor C1provided by MGI
Primary source
MGI:MGI:105942
See related
Ensembl:ENSMUSG00000031386 AllianceGenome:MGI:105942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HCF; HCF1
Summary
This gene encodes a transcription cofactor that regulates the progression of cell cycle and maintain the ability of embryonic stem cells to self-renew. The encoded protein is a large precursor that undergoes site-specific proteolytic cleavage to yield N- and C-terminal chains that form a non-covalent heterodimer. The encoded protein has been implicated in the regulation of expression of immediate early genes after herpes simplex virus infection and glucose-stimulated secretion of insulin by pancreatic beta cells. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in thymus adult (RPKM 54.5), adrenal adult (RPKM 25.7) and 28 other tissues See more
Orthologs
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Genomic context

See Hcfc1 in Genome Data Viewer
Location:
X A7.3; X 37.52 cM
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72986398..73011430, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73942792..73966995, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene renin binding protein Neighboring gene predicted gene 8545 Neighboring gene interleukin-1 receptor-associated kinase 1 Neighboring gene microRNA 5132

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H4-K16 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H4-K5 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H4-K8 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone H3-K4 methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dosage compensation by inactivation of X chromosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in release from viral latency IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1/2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of NSL complex ISO
Inferred from Sequence Orthology
more info
 
part_of Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
host cell factor 1
Names
VP16 accessory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411234.1NP_001398163.1  host cell factor 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL672002
  2. NM_008224.5NP_032250.2  host cell factor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_032250.2

    Status: REVIEWED

    Source sequence(s)
    AL672002
    Consensus CDS
    CCDS30218.1
    UniProtKB/Swiss-Prot
    Q61191, Q9QWH2
    Related
    ENSMUSP00000033761.7, ENSMUST00000033761.13
    Conserved Domains (6) summary
    PLN02153
    Location:12330
    PLN02153; epithiospecifier protein
    cd00063
    Location:18661895
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:3269
    Kelch_1; Kelch motif
    pfam13415
    Location:215263
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:134179
    Kelch_5; Kelch motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72986398..73011430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318387.3XP_017173876.1  host cell factor 1 isoform X3

    Conserved Domains (5) summary
    PLN02193
    Location:27322
    PLN02193; nitrile-specifier protein
    cd00063
    Location:18671896
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]
    pfam05109
    Location:441771
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13854
    Location:319351
    Kelch_5; Kelch motif
  2. XM_006527836.3XP_006527899.1  host cell factor 1 isoform X2

    Conserved Domains (5) summary
    PLN02193
    Location:27322
    PLN02193; nitrile-specifier protein
    cd00063
    Location:19101939
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]
    pfam05109
    Location:441771
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13854
    Location:319351
    Kelch_5; Kelch motif
  3. XM_006527835.3XP_006527898.1  host cell factor 1 isoform X1

    UniProtKB/TrEMBL
    B1AUX2
    Related
    ENSMUSP00000110012.3, ENSMUST00000114372.3
    Conserved Domains (5) summary
    PLN02193
    Location:27322
    PLN02193; nitrile-specifier protein
    cd00063
    Location:19111940
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]
    pfam05109
    Location:441771
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13854
    Location:319351
    Kelch_5; Kelch motif