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GPR155 G protein-coupled receptor 155 [ Homo sapiens (human) ]

Gene ID: 151556, updated on 17-Jun-2019

Summary

Official Symbol
GPR155provided by HGNC
Official Full Name
G protein-coupled receptor 155provided by HGNC
Primary source
HGNC:HGNC:22951
See related
Ensembl:ENSG00000163328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEP.7; PGR22; DEPDC3
Expression
Ubiquitous expression in stomach (RPKM 11.2), brain (RPKM 8.6) and 24 other tissues See more
Orthologs

Genomic context

See GPR155 in Genome Data Viewer
Location:
2q31.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (174431571..174494001, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (175296299..175351816, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene corepressor interacting with RBPJ, 1 Neighboring gene secernin 3 Neighboring gene uncharacterized LOC105373748 Neighboring gene replication protein A3, 14kDa pseudogene Neighboring gene RNA, U6 small nuclear 5, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31819, FLJ39346

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
integral membrane protein GPR155
Names
G-protein coupled receptor PGR22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033045.4NP_001028217.1  integral membrane protein GPR155 isoform 1

    See identical proteins and their annotated locations for NP_001028217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform.
    Source sequence(s)
    AC018470, AK056381, AL834154
    Consensus CDS
    CCDS2259.1
    UniProtKB/Swiss-Prot
    Q7Z3F1
    Related
    ENSP00000295500.4, ENST00000295500.8
    Conserved Domains (2) summary
    cd04443
    Location:751833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38366
    Mem_trans; Membrane transport protein
  2. NM_001267050.2NP_001253979.1  integral membrane protein GPR155 isoform 1

    See identical proteins and their annotated locations for NP_001253979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC018470, BC035037
    Consensus CDS
    CCDS2259.1
    UniProtKB/Swiss-Prot
    Q7Z3F1
    Related
    ENSP00000376334.2, ENST00000392551.6
    Conserved Domains (2) summary
    cd04443
    Location:751833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38366
    Mem_trans; Membrane transport protein
  3. NM_001267051.1NP_001253980.1  integral membrane protein GPR155 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC018470, AK056381, BC036681, DC334438
    Consensus CDS
    CCDS74605.1
    UniProtKB/Swiss-Prot
    Q7Z3F1
    UniProtKB/TrEMBL
    A0A087WXK4, Q49AJ5
    Related
    ENSP00000481104.1, ENST00000614352.4
    Conserved Domains (2) summary
    cd04443
    Location:723805
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38366
    Mem_trans; Membrane transport protein
  4. NM_152529.7NP_689742.4  integral membrane protein GPR155 isoform 1

    See identical proteins and their annotated locations for NP_689742.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC018470, AK315125
    Consensus CDS
    CCDS2259.1
    UniProtKB/Swiss-Prot
    Q7Z3F1
    Related
    ENSP00000376335.2, ENST00000392552.6
    Conserved Domains (2) summary
    cd04443
    Location:751833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38366
    Mem_trans; Membrane transport protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    174431571..174494001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003487.1XP_016858976.1  integral membrane protein GPR155 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z3F1
    Conserved Domains (2) summary
    cd04443
    Location:751833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38366
    Mem_trans; Membrane transport protein
  2. XM_017003486.2XP_016858975.1  integral membrane protein GPR155 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z3F1
    Conserved Domains (2) summary
    cd04443
    Location:751833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38366
    Mem_trans; Membrane transport protein
  3. XM_017003485.2XP_016858974.1  integral membrane protein GPR155 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z3F1
    Conserved Domains (2) summary
    cd04443
    Location:751833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38366
    Mem_trans; Membrane transport protein
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