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SLC16A14 solute carrier family 16 member 14 [ Homo sapiens (human) ]

Gene ID: 151473, updated on 22-Sep-2022

Summary

Official Symbol
SLC16A14provided by HGNC
Official Full Name
solute carrier family 16 member 14provided by HGNC
Primary source
HGNC:HGNC:26417
See related
Ensembl:ENSG00000163053 AllianceGenome:HGNC:26417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT14
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 4.6), brain (RPKM 4.6) and 24 other tissues See more
Orthologs
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Genomic context

See SLC16A14 in Genome Data Viewer
Location:
2q36.3
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230034982..230068924, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (230517639..230551553, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (230899698..230933640, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373924 Neighboring gene F-box protein 36 Neighboring gene RNA, U6 small nuclear 1027, pseudogene Neighboring gene uncharacterized LOC107985996 Neighboring gene uncharacterized LOC107985995 Neighboring gene RNY4 pseudogene 19 Neighboring gene SP110 nuclear body protein Neighboring gene SP140 nuclear body protein Neighboring gene SP140 nuclear body protein like Neighboring gene uncharacterized LOC105373925

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30794

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
monocarboxylate transporter 14
Names
MCT 14
monocarboxylic acid transporter 14
solute carrier family 16 (monocarboxylic acid transporters), member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152527.5NP_689740.2  monocarboxylate transporter 14

    See identical proteins and their annotated locations for NP_689740.2

    Status: VALIDATED

    Source sequence(s)
    AL833470, BC065524, DA044472
    Consensus CDS
    CCDS2473.1
    UniProtKB/Swiss-Prot
    Q7RTX9, Q96NI7
    Related
    ENSP00000295190.4, ENST00000295190.9
    Conserved Domains (1) summary
    cl26868
    Location:24490
    2A0111; oxalate/formate antiporter family transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    230034982..230068924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246353.5XP_005246410.1  monocarboxylate transporter 14 isoform X3

    Conserved Domains (2) summary
    cd06174
    Location:260442
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:24442
    2A0113; monocarboxylate transporter 1
  2. XM_047443523.1XP_047299479.1  monocarboxylate transporter 14 isoform X3

  3. XM_017003480.3XP_016858969.1  monocarboxylate transporter 14 isoform X1

    UniProtKB/Swiss-Prot
    Q7RTX9, Q96NI7
    Conserved Domains (1) summary
    cl26868
    Location:24490
    2A0111; oxalate/formate antiporter family transporter
  4. XM_011510751.4XP_011509053.1  monocarboxylate transporter 14 isoform X1

    See identical proteins and their annotated locations for XP_011509053.1

    UniProtKB/Swiss-Prot
    Q7RTX9, Q96NI7
    Conserved Domains (1) summary
    cl26868
    Location:24490
    2A0111; oxalate/formate antiporter family transporter
  5. XM_011510752.3XP_011509054.1  monocarboxylate transporter 14 isoform X2

    Related
    ENSP00000400352.1, ENST00000457406.5
    Conserved Domains (2) summary
    cd06174
    Location:37461
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:41457
    MFS_1; Major Facilitator Superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    230517639..230551553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)