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RMDN2 regulator of microtubule dynamics 2 [ Homo sapiens (human) ]

Gene ID: 151393, updated on 4-Jul-2021

Summary

Official Symbol
RMDN2provided by HGNC
Official Full Name
regulator of microtubule dynamics 2provided by HGNC
Primary source
HGNC:HGNC:26567
See related
Ensembl:ENSG00000115841 MIM:611872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RMD2; RMD4; RMD-2; FAM82A; BLOCK18; FAM82A1; PRO34163; PYST9371
Expression
Broad expression in adrenal (RPKM 5.4), spleen (RPKM 2.9) and 22 other tissues See more
Orthologs
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Genomic context

See RMDN2 in Genome Data Viewer
Location:
2p22.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (37920789..38069246)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38152430..38294281)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase receptor associated protein pseudogene Neighboring gene long intergenic non-protein coding RNA 211 Neighboring gene RMDN2 antisense RNA 1 Neighboring gene zinc finger protein 430 pseudogene Neighboring gene uncharacterized LOC107985872 Neighboring gene CYP1B1 promoter Neighboring gene cytochrome P450 family 1 subfamily B member 1 Neighboring gene uncharacterized LOC105374466 Neighboring gene CYP1B1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32954, FLJ38143, MGC33318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 
is_active_in mitotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
regulator of microtubule dynamics protein 2
Names
family with sequence similarity 82, member A
family with sequence similarity 82, member A1
microtubule-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170791.3NP_001164262.1  regulator of microtubule dynamics protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001164262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is shorter than isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC016689, AY358269, BC024243, BQ017142
    Consensus CDS
    CCDS54351.1
    UniProtKB/Swiss-Prot
    Q96LZ7
    Related
    ENSP00000346549.3, ENST00000354545.8
    Conserved Domains (1) summary
    sd00006
    Location:302352
    TPR; TPR repeat [structural motif]
  2. NM_001170792.3NP_001164263.1  regulator of microtubule dynamics protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001164263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is shorter than isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    BC024243, BQ017142
    Consensus CDS
    CCDS54351.1
    UniProtKB/Swiss-Prot
    Q96LZ7
    Related
    ENSP00000386004.1, ENST00000406384.5
    Conserved Domains (1) summary
    sd00006
    Location:302352
    TPR; TPR repeat [structural motif]
  3. NM_001170793.3NP_001164264.1  regulator of microtubule dynamics protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001164264.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF435956, BC024243, BQ017142
    Consensus CDS
    CCDS54352.1
    UniProtKB/Swiss-Prot
    Q96LZ7
    Related
    ENSP00000392977.2, ENST00000417700.6
    Conserved Domains (1) summary
    sd00006
    Location:157207
    TPR; TPR repeat [structural motif]
  4. NM_001322211.2NP_001309140.1  regulator of microtubule dynamics protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC016689, BQ017142
    Consensus CDS
    CCDS54351.1
    UniProtKB/Swiss-Prot
    Q96LZ7
    Conserved Domains (1) summary
    sd00006
    Location:302352
    TPR; TPR repeat [structural motif]
  5. NM_001322212.2NP_001309141.1  regulator of microtubule dynamics protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC009229, AC016689
    Conserved Domains (2) summary
    COG1196
    Location:69217
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00006
    Location:302352
    TPR; TPR repeat [structural motif]
  6. NM_144713.5NP_653314.3  regulator of microtubule dynamics protein 2 isoform 1

    See identical proteins and their annotated locations for NP_653314.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK057516, DB523982
    Consensus CDS
    CCDS1792.1
    UniProtKB/Swiss-Prot
    Q96LZ7
    UniProtKB/TrEMBL
    A0A0C4DFM4
    Related
    ENSP00000234195.3, ENST00000234195.7
    Conserved Domains (2) summary
    sd00006
    Location:480530
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:518565
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    37920789..38069246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532618.2XP_011530920.1  regulator of microtubule dynamics protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011530920.1

    Conserved Domains (2) summary
    COG1196
    Location:69217
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00006
    Location:302352
    TPR; TPR repeat [structural motif]
  2. XM_011532617.2XP_011530919.1  regulator of microtubule dynamics protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011530919.1

    Conserved Domains (2) summary
    COG1196
    Location:69217
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00006
    Location:302352
    TPR; TPR repeat [structural motif]
  3. XM_017003479.1XP_016858968.1  regulator of microtubule dynamics protein 2 isoform X8

    Conserved Domains (1) summary
    sd00006
    Location:157207
    TPR; TPR repeat [structural motif]
  4. XM_011532616.2XP_011530918.1  regulator of microtubule dynamics protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011530918.1

    Conserved Domains (2) summary
    COG1196
    Location:69217
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00006
    Location:302352
    TPR; TPR repeat [structural motif]
  5. XM_017003476.2XP_016858965.1  regulator of microtubule dynamics protein 2 isoform X6

  6. XM_017003478.1XP_016858967.1  regulator of microtubule dynamics protein 2 isoform X7

  7. XM_011532619.2XP_011530921.1  regulator of microtubule dynamics protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011530921.1

    Conserved Domains (2) summary
    COG1196
    Location:69217
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00006
    Location:302352
    TPR; TPR repeat [structural motif]
  8. XM_017003477.2XP_016858966.1  regulator of microtubule dynamics protein 2 isoform X6

  9. XM_011532615.3XP_011530917.2  regulator of microtubule dynamics protein 2 isoform X2

  10. XM_017003475.2XP_016858964.1  regulator of microtubule dynamics protein 2 isoform X4

    UniProtKB/Swiss-Prot
    Q96LZ7
    UniProtKB/TrEMBL
    A0A0C4DFM4
    Conserved Domains (2) summary
    sd00006
    Location:480530
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:518565
    TPR_11; TPR repeat
  11. XM_011532614.3XP_011530916.1  regulator of microtubule dynamics protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011530916.1

    Conserved Domains (2) summary
    sd00006
    Location:480530
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:518565
    TPR_11; TPR repeat
  12. XM_017003474.1XP_016858963.1  regulator of microtubule dynamics protein 2 isoform X3

  13. XM_011532613.3XP_011530915.1  regulator of microtubule dynamics protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011530915.1

    Conserved Domains (2) summary
    sd00006
    Location:480530
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:518565
    TPR_11; TPR repeat

RNA

  1. XR_939668.3 RNA Sequence

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