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LRATD1 LRAT domain containing 1 [ Homo sapiens (human) ]

Gene ID: 151354, updated on 5-Aug-2022

Summary

Official Symbol
LRATD1provided by HGNC
Official Full Name
LRAT domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20743
See related
Ensembl:ENSG00000162981 MIM:611234; AllianceGenome:HGNC:20743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSE1; FAM84A; PP11517
Summary
Involved in cell morphogenesis and cell motility. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon (RPKM 29.3), small intestine (RPKM 11.3) and 16 other tissues See more
Orthologs
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Genomic context

See LRATD1 in Genome Data Viewer
Location:
2p24.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (14632717..14651916)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (14663504..14682703)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (14772841..14792040)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985854 Neighboring gene long intergenic non-protein coding RNA 276 Neighboring gene RNA, U6 small nuclear 1288, pseudogene Neighboring gene NBAS subunit of NRZ tethering complex Neighboring gene Sharpr-MPRA regulatory region 966 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:15281925-15283124

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35392

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein LRATD1
Names
family with sequence similarity 84 member A
neurologic sensory protein 1
neurological/sensory 1
protein FAM84A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369364.1NP_001356293.1  protein LRATD1

    Status: VALIDATED

    Source sequence(s)
    AC011897
    UniProtKB/Swiss-Prot
    Q8TAM5
    Related
    ENSP00000330681.4, ENST00000331243.4
    Conserved Domains (1) summary
    cl21534
    Location:143223
    NLPC_P60; NlpC/P60 family
  2. NM_145175.4NP_660158.2  protein LRATD1

    See identical proteins and their annotated locations for NP_660158.2

    Status: VALIDATED

    Source sequence(s)
    AC011897, AJ417080, BX113099, HY017941
    Consensus CDS
    CCDS1684.1
    UniProtKB/Swiss-Prot
    Q8TAM5, Q96KN4
    Related
    ENSP00000295092.2, ENST00000295092.3
    Conserved Domains (1) summary
    cl21534
    Location:143223
    NLPC_P60; NlpC/P60 family

RNA

  1. NR_144632.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011897, BM998595

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    14632717..14651916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    14663504..14682703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001291410.1: Suppressed sequence

    Description
    NM_001291410.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.