Format

Send to:

Choose Destination

SLC38A11 solute carrier family 38 member 11 [ Homo sapiens (human) ]

Gene ID: 151258, updated on 13-Mar-2020

Summary

Official Symbol
SLC38A11provided by HGNC
Official Full Name
solute carrier family 38 member 11provided by HGNC
Primary source
HGNC:HGNC:26836
See related
Ensembl:ENSG00000169507 MIM:616526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AVT2
Expression
Broad expression in gall bladder (RPKM 4.2), stomach (RPKM 2.0) and 14 other tissues See more
Orthologs

Genomic context

See SLC38A11 in Genome Data Viewer
Location:
2q24.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (164898199..164955721, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (165754709..165812035, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 110 Neighboring gene RNA, 5S ribosomal pseudogene 111 Neighboring gene sodium voltage-gated channel alpha subunit 3 Neighboring gene sodium voltage-gated channel alpha subunit 2 Neighboring gene MAPRE1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
NHGRI GWA Catalog

General gene information

Markers

Homology

Clone Names

  • FLJ39822, MGC150450

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative sodium-coupled neutral amino acid transporter 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199148.1NP_001186077.1  putative sodium-coupled neutral amino acid transporter 11 isoform 1

    See identical proteins and their annotated locations for NP_001186077.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 4, encodes isoform 1.
    Source sequence(s)
    AK097141, AK293998
    Consensus CDS
    CCDS56142.1
    UniProtKB/Swiss-Prot
    Q08AI6
    Related
    ENSP00000386272.3, ENST00000409149.7
    Conserved Domains (1) summary
    cl00456
    Location:1362
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_001351537.1NP_001338466.1  putative sodium-coupled neutral amino acid transporter 11 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC019197
    Conserved Domains (1) summary
    cl00456
    Location:37418
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. NM_001351538.1NP_001338467.1  putative sodium-coupled neutral amino acid transporter 11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC019197, BC125157
    Consensus CDS
    CCDS56142.1
    Related
    ENSP00000386774.1, ENST00000409662.5
    Conserved Domains (1) summary
    cl00456
    Location:1362
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. NM_001351539.1NP_001338468.1  putative sodium-coupled neutral amino acid transporter 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC019197
    Conserved Domains (1) summary
    cl00456
    Location:1296
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. NM_001351540.1NP_001338469.1  putative sodium-coupled neutral amino acid transporter 11 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC019197
    Conserved Domains (1) summary
    cl00456
    Location:24223
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  6. NM_173512.2NP_775783.1  putative sodium-coupled neutral amino acid transporter 11 isoform 2

    See identical proteins and their annotated locations for NP_775783.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK097141, AK293998, BC125156
    Consensus CDS
    CCDS2224.1
    UniProtKB/Swiss-Prot
    Q08AI6
    Related
    ENSP00000306178.4, ENST00000303735.8
    Conserved Domains (1) summary
    cl00456
    Location:1340
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    164898199..164955721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003464.2XP_016858953.1  putative sodium-coupled neutral amino acid transporter 11 isoform X12

  2. XM_017003458.2XP_016858947.1  putative sodium-coupled neutral amino acid transporter 11 isoform X5

  3. XM_017003457.2XP_016858946.1  putative sodium-coupled neutral amino acid transporter 11 isoform X3

    Related
    ENSP00000387345.1, ENST00000409058.5
  4. XM_011510737.3XP_011509039.1  putative sodium-coupled neutral amino acid transporter 11 isoform X4

    Conserved Domains (2) summary
    COG0814
    Location:37389
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:37396
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. XM_017003456.2XP_016858945.1  putative sodium-coupled neutral amino acid transporter 11 isoform X2

  6. XM_006712337.4XP_006712400.1  putative sodium-coupled neutral amino acid transporter 11 isoform X7

    Conserved Domains (1) summary
    cl00456
    Location:37364
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  7. XM_017003455.2XP_016858944.1  putative sodium-coupled neutral amino acid transporter 11 isoform X1

  8. XM_024452729.1XP_024308497.1  putative sodium-coupled neutral amino acid transporter 11 isoform X13

    Conserved Domains (1) summary
    cl00456
    Location:24223
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  9. XM_017003459.2XP_016858948.1  putative sodium-coupled neutral amino acid transporter 11 isoform X6

  10. XM_017003463.2XP_016858952.1  putative sodium-coupled neutral amino acid transporter 11 isoform X11

    Conserved Domains (1) summary
    cl00456
    Location:1296
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  11. XM_017003465.2XP_016858954.1  putative sodium-coupled neutral amino acid transporter 11 isoform X12

  12. XM_017003460.1XP_016858949.1  putative sodium-coupled neutral amino acid transporter 11 isoform X8

  13. XM_017003461.2XP_016858950.1  putative sodium-coupled neutral amino acid transporter 11 isoform X9

  14. XM_017003462.1XP_016858951.1  putative sodium-coupled neutral amino acid transporter 11 isoform X10

RNA

  1. XR_001738648.1 RNA Sequence

Support Center