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PPP1R1C protein phosphatase 1 regulatory inhibitor subunit 1C [ Homo sapiens (human) ]

Gene ID: 151242, updated on 24-Nov-2020

Summary

Official Symbol
PPP1R1Cprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 1Cprovided by HGNC
Primary source
HGNC:HGNC:14940
See related
Ensembl:ENSG00000150722 MIM:613240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPP5
Summary
Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]
Expression
Biased expression in heart (RPKM 4.6), testis (RPKM 4.4) and 5 other tissues See more
Orthologs

Genomic context

See PPP1R1C in Genome Data Viewer
Location:
2q31.3-q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (181954480..182131385)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (182818968..182996109)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NEUROD1-SSFA2 intergenic CAGE-defined mid-level expression enhancer Neighboring gene ITPR interacting domain containing 2 Neighboring gene keratin 18 pseudogene 29 Neighboring gene uncharacterized LOC102724288 Neighboring gene RNA, 5S ribosomal pseudogene 113 Neighboring gene phosphodiesterase 1A Neighboring gene RNA, 7SL, cytoplasmic 267, pseudogene Neighboring gene uncharacterized LOC101929976

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 1C
Names
PP1 inhibitor protein 5
inhibitor-5 of protein phosphatase 1
protein phosphatase 1 regulatory subunit 1A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080545.3NP_001074014.1  protein phosphatase 1 regulatory subunit 1C isoform 2

    See identical proteins and their annotated locations for NP_001074014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and differs in the 3' UTR compared to variant 1. The resulting protein is shorter compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
    Source sequence(s)
    AC009962, AC011291, AC064837
    Consensus CDS
    CCDS46468.1
    UniProtKB/Swiss-Prot
    Q8WVI7
    Conserved Domains (1) summary
    pfam05395
    Location:285
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
  2. NM_001261424.2NP_001248353.1  protein phosphatase 1 regulatory subunit 1C isoform 1

    See identical proteins and their annotated locations for NP_001248353.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC009962, AC011291, AF494535
    Consensus CDS
    CCDS58740.1
    UniProtKB/Swiss-Prot
    Q8WVI7
    Related
    ENSP00000280295.3, ENST00000280295.7
    Conserved Domains (1) summary
    pfam05395
    Location:292
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
  3. NM_001261425.2NP_001248354.1  protein phosphatase 1 regulatory subunit 1C isoform 2

    See identical proteins and their annotated locations for NP_001248354.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein is shorter compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
    Source sequence(s)
    AC009962, AC011291, AK129898, BX647581
    Consensus CDS
    CCDS46468.1
    UniProtKB/Swiss-Prot
    Q8WVI7
    Related
    ENSP00000386359.3, ENST00000409137.7
    Conserved Domains (1) summary
    pfam05395
    Location:285
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

RNA

  1. NR_048566.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA321774, AC009962, AC011291, BC017943
  2. NR_048567.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains alternate 5' and 3' exons, and lacks two alternate exons compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
    Source sequence(s)
    AC011291, AK311571, BI792375

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    181954480..182131385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003451.1XP_016858940.1  protein phosphatase 1 regulatory subunit 1C isoform X1

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