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CCNYL1 cyclin Y like 1 [ Homo sapiens (human) ]

Gene ID: 151195, updated on 5-Aug-2022

Summary

Official Symbol
CCNYL1provided by HGNC
Official Full Name
cyclin Y like 1provided by HGNC
Primary source
HGNC:HGNC:26868
See related
Ensembl:ENSG00000163249 AllianceGenome:HGNC:26868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within flagellated sperm motility; regulation of protein kinase activity; and spermatogenesis. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 8.2), testis (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See CCNYL1 in Genome Data Viewer
Location:
2q33.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (207711640..207756174)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (208185841..208230386)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (208576364..208620898)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 2 Neighboring gene RNA, U6 small nuclear 664, pseudogene Neighboring gene microRNA 4775 Neighboring gene frizzled class receptor 5 Neighboring gene Sharpr-MPRA regulatory region 8784

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40432

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142300.2NP_001135772.1  cyclin-Y-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001135772.1

    Status: VALIDATED

    Source sequence(s)
    AA731590, AK026922, AK097751, BC067253, BM772734, CB158848, CN482952, DA730784
    Consensus CDS
    CCDS46503.1
    UniProtKB/Swiss-Prot
    Q8N7R7
    Related
    ENSP00000342344.5, ENST00000339882.9
    Conserved Domains (1) summary
    pfam00134
    Location:119234
    Cyclin_N; Cyclin, N-terminal domain
  2. NM_001330218.2NP_001317147.1  cyclin-Y-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC096772
    Consensus CDS
    CCDS82564.1
    UniProtKB/Swiss-Prot
    Q6NX60, Q8N7R7
    Related
    ENSP00000295414.3, ENST00000295414.8
    Conserved Domains (1) summary
    pfam00134
    Location:163285
    Cyclin_N; Cyclin, N-terminal domain
  3. NM_152523.3NP_689736.1  cyclin-Y-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_689736.1

    Status: VALIDATED

    Source sequence(s)
    AA731590, AK026922, AK095479, AK097751, BM772734, CB158848, DA730784
    Consensus CDS
    CCDS2377.1
    UniProtKB/Swiss-Prot
    Q8N7R7
    Related
    ENSP00000376045.3, ENST00000392209.7
    Conserved Domains (1) summary
    pfam00134
    Location:93215
    Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    207711640..207756174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    208185841..208230386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)