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ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 [ Homo sapiens (human) ]

Gene ID: 151188, updated on 7-Jan-2024

Summary

Official Symbol
ARL6IP6provided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 6 interacting protein 6provided by HGNC
Primary source
HGNC:HGNC:24048
See related
Ensembl:ENSG00000177917 MIM:616495; AllianceGenome:HGNC:24048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP6; AIP-6; PFAAP1
Summary
Predicted to be located in nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 7.1), bone marrow (RPKM 6.2) and 25 other tissues See more
Orthologs
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Genomic context

See ARL6IP6 in Genome Data Viewer
Location:
2q23.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (152717648..152762396)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (153170194..153214953)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (153574162..153618910)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373689 Neighboring gene uncharacterized LOC105373688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153183153-153183652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153258063-153258564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153258565-153259064 Neighboring gene Sharpr-MPRA regulatory region 2662 Neighboring gene formin like 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:153280187-153280913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153280914-153281639 Neighboring gene Sharpr-MPRA regulatory region 469 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:153309665-153310256 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:153310257-153310847 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:153312623-153313213 Neighboring gene nuclear distribution C pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:153357706-153358281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16649 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:153474731-153475930 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:153502126-153503325 Neighboring gene NANOG hESC enhancer GRCh37_chr2:153508427-153509132 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:153519134-153520333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16650 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:153557503-153558702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153558975-153559476 Neighboring gene pre-mRNA processing factor 40 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16655 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:153574523-153575228 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:153661367-153661578 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:153702825-153704024 Neighboring gene ubiquilin 4 pseudogene 2 Neighboring gene uncharacterized LOC105373691 Neighboring gene NANOG hESC enhancer GRCh37_chr2:153842337-153842838

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC33864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 6-interacting protein 6
Names
ADP-ribosylation factor GTPase 6 interacting protein 6
ADP-ribosylation factor-like 6 interacting protein 6
ADP-ribosylation-like factor 6 interacting protein 6
ARL-6-interacting protein 6
phosphonoformate immuno-associated protein 1
regulated by phosphonoformate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053091.1 RefSeqGene

    Range
    5928..49704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350068.2NP_001336997.1  ADP-ribosylation factor-like protein 6-interacting protein 6 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC079344
    Conserved Domains (1) summary
    pfam15062
    Location:42118
    ARL6IP6; Haemopoietic lineage transmembrane helix
  2. NM_001371972.1NP_001358901.1  ADP-ribosylation factor-like protein 6-interacting protein 6 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC079344
    Consensus CDS
    CCDS92880.1
    UniProtKB/TrEMBL
    A0A8I5KQ30, B3KMZ5
    Related
    ENSP00000509648.1, ENST00000686080.1
    Conserved Domains (1) summary
    pfam15062
    Location:147183
    ARL6IP6; Haemopoietic lineage transmembrane helix
  3. NM_152522.7NP_689735.1  ADP-ribosylation factor-like protein 6-interacting protein 6 isoform a

    See identical proteins and their annotated locations for NP_689735.1

    Status: VALIDATED

    Source sequence(s)
    AC079344
    Consensus CDS
    CCDS2197.1
    UniProtKB/Swiss-Prot
    B2RDS6, Q7Z4G7, Q8N6S5
    UniProtKB/TrEMBL
    B3KMZ5
    Related
    ENSP00000315357.5, ENST00000326446.10
    Conserved Domains (1) summary
    pfam15062
    Location:138214
    ARL6IP6; Haemopoietic lineage transmembrane helix

RNA

  1. NR_024526.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344
  2. NR_146422.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344
  3. NR_146423.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344
  4. NR_146424.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344
  5. NR_146425.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344
  6. NR_146426.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344
  7. NR_146427.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344
  8. NR_146428.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344
  9. NR_146429.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344
  10. NR_146430.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344
  11. NR_146431.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079344

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    152717648..152762396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007069661.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    153170194..153214953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008486292.1 RNA Sequence