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Has3 hyaluronan synthase 3 [ Mus musculus (house mouse) ]

Gene ID: 15118, updated on 28-Sep-2021

Summary

Official Symbol
Has3provided by MGI
Official Full Name
hyaluronan synthase 3provided by MGI
Primary source
MGI:MGI:109599
See related
Ensembl:ENSMUSG00000031910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Broad expression in CNS E18 (RPKM 2.9), whole brain E14.5 (RPKM 2.4) and 23 other tissues See more
Orthologs
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Genomic context

See Has3 in Genome Data Viewer
Location:
8 D3; 8 53.28 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107596874..107609534)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106870242..106882902)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (109394142..109406802)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cadherin 1 Neighboring gene transport and golgi organization 6 Neighboring gene predicted gene, 34197 Neighboring gene predicted gene, 53451 Neighboring gene ES cell cis-regulatory motif 8a Neighboring gene CTF8, chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein Neighboring gene UTP4 small subunit processome component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hyaluronan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hyaluronan synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hyaluronan synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in hyaluranon cable ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hyaluronan synthase 3
Names
HA synthase 3
hyaluronate synthase 3
hyaluronic acid synthase 3
NP_001317977.1
NP_032243.2
XP_006530763.1
XP_006530764.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331048.1NP_001317977.1  hyaluronan synthase 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC123864, AK028582
    Consensus CDS
    CCDS22640.1
    UniProtKB/Swiss-Prot
    O08650
    Related
    ENSMUSP00000135303.2, ENSMUST00000176144.8
    Conserved Domains (2) summary
    cd06434
    Location:87365
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    cl01224
    Location:403493
    DUF805; Protein of unknown function (DUF805)
  2. NM_008217.4NP_032243.2  hyaluronan synthase 3

    See identical proteins and their annotated locations for NP_032243.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC140328, AK028582, BY132822
    Consensus CDS
    CCDS22640.1
    UniProtKB/Swiss-Prot
    O08650
    Related
    ENSMUSP00000034385.6, ENSMUST00000034385.12
    Conserved Domains (2) summary
    cd06434
    Location:87365
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    cl01224
    Location:403493
    DUF805; Protein of unknown function (DUF805)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    107596874..107609534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530701.4XP_006530764.1  hyaluronan synthase 3 isoform X1

    See identical proteins and their annotated locations for XP_006530764.1

    UniProtKB/Swiss-Prot
    O08650
    Conserved Domains (2) summary
    cd06434
    Location:87365
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    cl01224
    Location:403493
    DUF805; Protein of unknown function (DUF805)
  2. XM_006530700.4XP_006530763.1  hyaluronan synthase 3 isoform X1

    See identical proteins and their annotated locations for XP_006530763.1

    UniProtKB/Swiss-Prot
    O08650
    Conserved Domains (2) summary
    cd06434
    Location:87365
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    cl01224
    Location:403493
    DUF805; Protein of unknown function (DUF805)
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