U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Has2 hyaluronan synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 15117, updated on 3-May-2022

Summary

Official Symbol
Has2provided by MGI
Official Full Name
hyaluronan synthase 2provided by MGI
Primary source
MGI:MGI:107821
See related
Ensembl:ENSMUSG00000022367 AllianceGenome:MGI:107821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables hyaluronan synthase activity. Involved in several processes, including circulatory system development; extracellular polysaccharide biosynthetic process; and hyaluronan biosynthetic process. Acts upstream of or within bone morphogenesis and hyaluronan metabolic process. Located in cytoplasmic vesicle and plasma membrane raft. Is expressed in several structures, including alimentary system; brain; heart; sensory organ; and skin. Orthologous to human HAS2 (hyaluronan synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 5.1), CNS E11.5 (RPKM 2.1) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Has2 in Genome Data Viewer
Location:
15 D1; 15 23.31 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (56529023..56557942, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (56665627..56694546, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (56497182..56526101, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41326 Neighboring gene predicted gene, 53891 Neighboring gene hyaluronan synthase 2, opposite strand Neighboring gene VISTA enhancer mm1164 Neighboring gene predicted gene, 38516

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hyaluronan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hyaluronan synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hyaluronan synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in atrioventricular canal development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extracellular matrix assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in extracellular matrix assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extracellular polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in extracellular polysaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hyaluronan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hyaluronan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hyaluronan metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hyaluronan synthase 2
Names
HA synthase 2
hyaluronan synthase homolog
hyaluronate synthase 2
hyaluronic acid synthase 2
NP_032242.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008216.3NP_032242.3  hyaluronan synthase 2

    See identical proteins and their annotated locations for NP_032242.3

    Status: VALIDATED

    Source sequence(s)
    BC080281, BY110777
    Consensus CDS
    CCDS27480.1
    UniProtKB/Swiss-Prot
    P70312
    Related
    ENSMUSP00000062212.8, ENSMUST00000050544.8
    Conserved Domains (1) summary
    cd06434
    Location:84361
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    56529023..56557942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)